grant
Mediators of chronicity in autoimmune endocrinopathies.
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 10 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AIDPAcute Autoimmune NeuropathyAcute Infective PolyneuritisAcute Inflammatory Demyelinating PolyradiculoneuropathyAcute Inflammatory PolyneuropathyAcute Inflammatory PolyradiculoneuropathyAntigensAssayAutoimmuneAutoimmune DiabetesAutoimmune DiseasesAutoimmune ResponsesAutoimmune StatusAutoimmune thyroiditisAutoimmunityB cell lymphoma 6B-Cell CLL/Lymphoma-6 GeneBCL5BCL6BCL6 geneBasal Transcription FactorBasal transcription factor genesBeta CellBioassayBiologicalBiological AssayBody TissuesBrittle Diabetes MellitusCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCellsChromatinChronicChronic DiseaseChronic IllnessChronic Lymphocytic ThyroiditisChronic thyroiditisClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCompetenceCys-His2 Zinc Finger Transcription Factor GeneDataDevelopmentDiseaseDisorderEffector CellEndocrineEndocrine Gland SecretionEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFaceFailureGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGoalsGuillain Barré SyndromeGuillaine-Barre SyndromeHashimoto DiseaseHashimoto's DiseaseHashimoto's StrumaHashimoto's ThyroiditisHashimoto's syndromeHashimotos DiseaseHormone secretionHormonesHumanHumulin RIDDMImmuneImmune mediated therapyImmune responseImmunesImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyImpairmentInfectionInfiltrationInsulinInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusInterruptionJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusLAZ-3 GeneLAZ3Landry's paralysisLandry-Guillain-Barre SyndromeLong-term infectionLymphocytic ThyroiditisLymphomatous ThyroiditisMediatingMediatorMemoryMiceMice MammalsModelingModern ManMolecularMurineMusMyelinNovolin ROnset of illnessPNS DiseasesPathogenicityPathway interactionsPatientsPeripheral Nerve DiseasesPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPhysiologicPhysiologicalPlayPopulationProgenitor CellsProliferatingRNA ExpressionRegimenRegular InsulinResearch ResourcesResidualResidual stateResourcesRoleStem Cell likeSudden-Onset Diabetes MellitusSymptomsT cell responseT-Cell ActivationT1 DMT1 diabetesT1DT1DMT8 CellsT8 LymphocytesTeff cellTestingTherapeuticTherapeutic HormoneThyroidThyroid GlandThyroid Gland HormoneThyroid Head and NeckThyroid HormonesTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusViral DiseasesVirus DiseasesZNF51ZNF51 GeneZinc Finger Protein 51 Geneactivate T cellsacute idiopathic polyneuritisacute post-infectious polyneuropathyacute postinfectious polyneuropathyantagonismantagonistanti-viral immunityantiviral immunityautoimmune attackautoimmune conditionautoimmune destructionautoimmune disorderautoimmune endocrine diseaseautoimmune endocrine disorderautoimmune endocrinopathiesautoimmune pathogenesisautoimmunity diseasebiologicblood glucose regulationchronic disorderchronic infectioncytotoxicdevelopmentaldisease onsetdisorder onseteffector T cellepigenetic regulationepigeneticallyfacesfacialgenome editinggenomic editingglucose controlglucose homeostasisglucose regulationhormonal secretionhost responseimmune drugsimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunologic therapeuticsimmunoresponseimmunotherapeuticsimmunotherapy agentinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmouse modelmultiomicsmultiple omicsmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetpanomicspathwayperipheral bloodpersistent infectionpreventpreventingprogenitorprogenitor capacityprogenitor cell likeprogenitor cell poolprogenitor cell populationprogenitor cell regenerationprogenitor cell self renewalprogenitor poolprogenitor populationprogenitor regenerationprogenitor self renewalprogenitor-likeself-renewself-renewalsmall molecular inhibitorsmall molecule inhibitorsocial rolestemstem and progenitor cell populationstem and progenitor cell regenerationstem and progenitor cell self renewalstem cell characteristicsstem cell poolstem cell populationstem cell regenerationstem cell self renewalstem cellsstem-likestemnesstranscription factortranslational opportunitiestranslational potentialtype I diabetestype one diabetesviral infectionvirus infectionvirus-induced diseaseβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY / ABSTRACT (PRINCIPAL PROJECT)
PRINCIPAL PROJECT: Molecular and cellular mechanisms of chronicity in autoimmune
endocrinopathies
Autoimmune endocrinopathies are chronic diseases, in which patients suffer permanent tissue damage and
require lifelong hormone replacement. In Type 1 Diabetes (T1D), for example, autoimmune destruction…
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