grant
Mechanosensitive Mechanisms of Premature Calcification in Bicuspid Aortic Valve Disease
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY202621+ years oldATP ReceptorsAddressAdultAdult HumanAffectAortic StenosisAortic Valve StenosisAortic valvular disordersBicuspid ValveBiomechanicsBirth DefectsBlood flowBody TissuesCalcifiedCardiac MalformationCardiac ValvesCell Communication and SignalingCell SignalingClinical ManagementClinical TreatmentComplicationComputer ModelsComputerized ModelsCongenital AbnormalityCongenital Anatomical AbnormalityCongenital Cardiac DefectsCongenital DefectsCongenital DeformityCongenital Heart DefectsCongenital MalformationDataData SetDevelopmentDiseaseDisease ProgressionDisorderEndothelial CellsExpression SignatureFoundationsGene ExpressionGene Expression ProfileGenesGoalsHealthHeart MalformationHeart ValvesImpairmentIndividualIntermediary MetabolismIntracellular Communication and SignalingLeftLifeMechanical StressMediatingMedicalMetabolic ProcessesMetabolismMiceMice MammalsMitral ValveModelingMolecularMolecular Biology TechniquesMurineMusOperative ProceduresOperative Surgical ProceduresOutcomeOutcome StudyPathologicPathological ConstrictionPatientsPatternPopulationPredispositionPurine ReceptorsPurinergic ReceptorsPurinoceptorQOLQuality of lifeReportingResearchSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStenosisStressStructural defectStructural malformationSurgicalSurgical InterventionsSurgical ProcedureSusceptibilitySystemTestingTissuesTrainingWorkabnormal heart developmentadult youthadulthoodantagonismantagonistaortic valveaortic valve defectaortic valve diseaseaortic valve disorderaortic valve replacementaortic valvular diseasebicuspid aortic valvebiological signal transductionbiomechanicalcalcificationclinical interventionclinical therapycomputational modelingcomputational modelscomputer based modelscomputerized modelingcongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationdevelopmentaldifferential expressiondifferentially expresseddrug developmentearly onseteffective therapyeffective treatmentgene expression patterngene expression signaturehuman datahuman diseasehuman modelin vitro Assayin vivoinnovateinnovationinnovativeinsightinterstitial cellmodel of humanmolecular biomarkermolecular markermouse modelmurine modelosteogenicprematureprematuritypreventpreventingprogramsresponseshear stressspatial RNA sequencingspatial and temporalspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial temporalspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsspatiotemporalstructural abnormalitiesstructural anomaliessurgerytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttranscriptional differencestranscriptional profiletranscriptional signaturetranslational medicinetrial regimentrial treatmentyoung adultyoung adult ageyoung adulthood
Description preview
PROJECT SUMMARY
Bicuspid aortic valve (BAV) disease is the most prevalent congenital heart disease, affecting ~2% of the
population worldwide. This disorder is characterized by the formation of two, rather than three valve cusps,
leading to narrowing of the valve opening and increased mechanical stress. The structural defect is not what
requires…
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