grant
Mechanobiology of Bruchs membrane during aging: Implications for age-related retinal degenerations.
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 15 Apr 2026Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DActomyosinAgeAge related macular degenerationAge-Related MaculopathyAgingAmino AcidsAutoregulationBiologicalBiological MarkersBiomechanicsBlindnessBody TissuesBruch MembraneBruch's basal membrane structureBruch's membraneBruchs membraneCancersCell BodyCell-Extracellular MatrixCellsComplexDataDiseaseDisease ReservoirsDisorderECMElderlyExtracellular MatrixExtracellular Matrix ProteinsEyeEyeballFundus dystrophyGlycolysisHealthHomeostasisHumanInferiorIntermediary MetabolismLamina Basalis ChoroideaeMMPsMalignant NeoplasmsMalignant TumorMapsMatrix MetalloproteinasesMechanicsMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModern ManMolecularMorphogenesisMurineMusNasalNasal Passages NoseNoseOrganPathogenesisPathologyPathway interactionsPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPlayPropertyProteinsPublishingRegulationReportingRespiratory System, Nose, Nasal PassagesRisk FactorsRoleSorsby's fundus dystrophyStructureSupporting CellTestingTissuesViscosityadvanced ageage associatedage associated declineage associated diseaseage associated disorderage associated impairmentage associated retinal degenerationage associated retinal degenerative diseaseage correlatedage dependentage dependent declineage dependent diseaseage dependent disorderage dependent impairmentage dependent macular degenerationage dependent retinal degenerationage induced macular degenerationage linkedage relatedage related declineage related human diseaseage related macular diseaseage related macular dystrophyage related retinal degenerationage related retinal degenerative diseaseage specificage-related diseaseage-related disorderage-related impairmentagesaging associatedaging processaging relatedaging related retinal degenerationaminoacidbio-markersbiologicbiologic markerbiomarkerbiomechanicalcrosslinkdecline with agegeriatricinsightinterestmaculamacularmalignancymechanicmechanicalmechanical forcemechanical propertiesmorphogenetic processneoplasm/cancerpathwayphysical propertyscaffoldscaffoldingsenile macular diseasesenior citizensocial rolespatial and temporalspatial temporalspatiotemporalthree dimensionalvision lossvisual loss
Description preview
PROJECT SUMMARY
Aging is a significant risk factor for age-related macular degeneration AMD, a leading cause of blindness among the
elderly. Aging and AMD induce progressive changes in Bruch’s membrane but to varying extents. There is increasing
evidence that the physical properties of tissues, particularly the extracellular matrix (ECM) can…
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