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Mechanistically Dissecting Glycolysis Regulation by Lactate and Its Therapeutic Potential in Cancer

Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Jan 2023Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025ATP SynthesisATP Synthesis PathwayAcuteAnti-diabetic AgentsAnti-diabetic DrugsAssayBioassayBiochemicalBiochemistryBioenergeticsBiological AssayBiological ChemistryBiomassBlood SerumCancer TreatmentCancer cell lineCancersCarbonCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationChemicalsCitric Acid CycleClinicalComplexConsumptionD-GlucoseDataDevelopment PlansDevelopment and ResearchDextroseDoctor of PhilosophyElectron TransportEnvironmentEnzyme GeneEnzymesEquilibriumFDA approvedGeneralized GrowthGeneticGlucoseGlycolysisGoalsGrowthImageIn VitroIntermediary MetabolismKnock-outKnockoutKnowledgeKrebs CycleLC/MSLaboratory ResearchMSKCCMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMemorial Sloan-Kettering Cancer CenterMentorshipMetabolicMetabolic ProcessesMetabolismMethodsMitochondriaNutrientOrganellesOxidative PhosphorylationOxidative Phosphorylation PathwayPDX modelPatient derived xenograftPermeabilityPh.D.PhDPhenforminPhenylethylbiguanidePhosphorylation InhibitionPhysiciansPostdocPostdoctoral FellowProductionProliferatingProteinsPyruvateR & DR&DRegulationReporterResearchResearch AssociateScientistSerumSourceTCA cycleTherapeuticTissue GrowthTrainingTricarboxylic Acid CycleUniversitiesWarburg Effectaerobic glycolysisanti-cancer therapyanti-diabeticbalancebalance functioncancer cellcancer cell metabolismcancer metabolismcancer microenvironmentcancer therapycancer-directed therapycareer developmentclinical trainingdesigndesigningelectron transferextracellularimage-based methodimagingimaging methodimaging modalityin vivoinhibitorinsightliquid chromatography mass spectrometrymalignancymedical collegemedical schoolsmetabolism measurementmetabolomicsmetabonomicsmitochondrialneoplasm/cancernovelontogenyoxidationpatient derived xenograft modelpost-docpost-doctoralpost-doctoral traineeresearch and developmentresearch associatesresponseschool of medicineskillstumortumor cell metabolismtumor metabolismtumor microenvironment

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PROJECT SUMMARY/ABSTRACT
Glucose is an essential fuel for cancer cell proliferation in serving both as a substrate for ATP production and
as an irreplaceable carbon source for biomass accumulation. Cancer cells are especially addicted to glucose
but only to secrete the majority as lactate (known as aerobic glycolysis or Warburg effect), thereby…

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