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Mechanistic Elucidation of Class Switch Recombination and Somatic Hypermutation
Organization SLOAN-KETTERING INST CAN RESEARCHLocation NEW YORK, UNITED STATESPosted 1 Jul 2009Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY202519S Gamma Globulin2'-deoxy-cytidine7S Gamma GlobulinAICDAAICDA proteinAID geneAID proteinATP phosphohydrolaseATPaseATPase DomainAdenosine TriphosphataseAffinityAmino Acids ActivationAntigensB blood cellsB cellB cellsB lymphomaB-Cell LymphomasB-CellsB-LymphocytesB-cellBase Excision RepairsBindingCDA2 proteinCHD4CHD4 geneCell BodyCell DeathCell Mediated ImmunologyCell-Mediated ImmunityCellsCellular ImmunityChromatinChromodomain Helicase DNA-Binding Protein 4Chromosomal dislocationChromosomal translocationClass SwitchingClass SwitchingsConstant RegionCytosine DeoxyribonucleosideCytosine DeoxyribosideDNADNA AlterationDNA Base Excision RepairDNA DamageDNA Damage RepairDNA Double Strand BreakDNA InjuryDNA RecombinationDNA RepairDNA Repair GeneDNA Sequence AlterationDNA mutationDNA repair proteinDeaminationDeletion MutationDeoxycytidineDeoxyribonucleic AcidDeoxyuridineDouble Strand Break RepairExonsFailureFundingGeneralized GrowthGenerationsGenesGeneticGenetic AlterationGenetic ChangeGenetic RecombinationGenetic TranslocationGenetic defectGenetic mutationGerminoblastic SarcomaGerminoblastomaGoalsGrowthHeavy-Chain ImmunoglobulinsHumanIg Constant RegionIg GenesIg Somatic HypermutationIgAIgEIgGIgMImmune responseImmunityImmunodeficiency DisorderImmunodeficiency SyndromeImmunoglobulin AImmunoglobulin Class SwitchingImmunoglobulin Class SwitchingsImmunoglobulin Constant RegionImmunoglobulin EImmunoglobulin GImmunoglobulin GenesImmunoglobulin Isotype-Switch RecombinationImmunoglobulin MImmunoglobulin Somatic HypermutationImmunoglobulin Switch RecombinationImmunologic Deficiency SyndromesImmunological Deficiency SyndromesImpairmentIsotype SwitchingIsotype SwitchingsKI miceKnock-in MouseKnowledgeLesionLymphomaMalignant LymphomaMature B-CellMature B-LymphocyteMediatingMi2-BetaMiceMice MammalsMismatch RepairModelingModern ManMolecularMolecular InteractionMurineMusMutagenic ProcessMutant Strains MiceMutateMutationNucleosomesOncogenesisPathologic MutagenesisPathologic Mutagenic ProcessPatientsPhasePhenocopyPost-Replication Mismatch RepairProteinsReactionRecombinationReticulolymphosarcomaRoleSequence AlterationSwitch RecombinationTestingTissue GrowthUnscheduled DNA SynthesisWorkactivation-induced cytidine deaminaseactivation-induced deaminasecancer typechromosome dislocationchromosome translocationdensityexperimentexperimental researchexperimental studyexperimentsflu infectionflu virus infectiongenome integritygenome mutationgenomic alterationgenomic integrityhost responsehypoimmunityimmune deficiencyimmune deficiency disorderimmune system responseimmunodeficiencyimmunogenimmunoresponseinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza virus infectioninsightknockin micemouse modelmouse mutantmurine modelnecrocytosisnovelontogenypreservationpreventpreventingrecruitrepairrepairedresponsesocial rolesomatic hypermutationtooltumorigenesisunpublished works
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Description preview
ABSTRACT
Upon encountering antigens, mature B cells express activation induced cytidine deaminase (AID) and undergo
immunoglobulin heavy chain (Igh) class switch recombination (CSR) and somatic hypermutation (SHM). CSR
proceeds through the obligate generation of DNA double strand breaks (DSBs), which constitute one of the
most toxic lesions that…
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