grant
Mechanistic Characterization of the Replication Stress Response
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 15 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Cancer TreatmentCancersCell BodyCell LineCellLineCellsCharacteristicsChromatinComplexDNADNA DamageDNA Damage RepairDNA InjuryDNA PolymerasesDNA RepairDNA ReplicationDNA SynthesisDNA biosynthesisDNA mutationDNA replication forkDNA-Dependent DNA PolymerasesDNA-Directed DNA PolymeraseData SetDefectDeoxyribonucleic AcidDevelopmentDiseaseDisorderDoseEnzyme GeneEnzymesExposure toFunctional RNAGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGrantLinkMaintenanceMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMolecularMutationNon-Polyadenylated RNANoncoding RNANontranslated RNANucleotide BiosynthesisOrganismPathogenesisPathway interactionsPostdocPostdoctoral FellowProcessR-Series Research ProjectsR01 MechanismR01 ProgramRNARNA BindingRNA Gene ProductsRNA HelicaseRNA boundRegulationResearch AssociateResearch GrantsResearch Project GrantsResearch ProjectsResearch ResourcesResourcesRibonucleic AcidRoleSS DNA BPSingle-Stranded DNASingle-Stranded DNA-Binding ProteinSourceStrains Cell LinesUnscheduled DNA SynthesisUntranslated RNAWorkanti-cancer therapyassaultbiochemical toolsbiochemistry toolsbiological adaptation to stresscancer therapycancer-directed therapycultured cell linedevelopmentalentire genomefull genomegenome mutationimprovedinsightliving systemmalignancyneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynoncodingnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypost-docpost-doctoralpost-doctoral traineereaction; crisisrepairrepairedreplication forkreplication stressresearch associatesresponserestorationsocial rolessDNAstress responsestress; reactionwhole genome
Description preview
PROJECT SUMMARY
Accurate DNA replication is a fundamental process that governs the survival of every organism.
Cellular DNA is under constant assault from various sources. The cellular replication machinery
frequently encounters and is severely vulnerable to agents that stall its advancement, leading to
replicative errors, development of…
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