grant
Mechanistic characterization of JNK2α variants in alcohol-caused heart failure
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 20 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025ATP2A2Absolute ethanolAddressAlcohol Chemical ClassAlcohol DrinkingAlcohol abuseAlcohol consumptionAlcoholicAlcoholic CardiomyopathyAlcoholismAlcoholsAnimalsApoptosisApoptosis PathwayAssayAttentionAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBindingBioassayBiochemicalBiochemistryBioinformaticsBiological AssayBiological ChemistryBoozerC-jun Amino-Terminal KinaseC-jun Kinase-1C-jun N-Terminal Kinase 1COVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCardiacCardiac Muscle CellsCardiac MyocytesCardiac OutputCardiocyteCardiovascular DiseasesCell Communication and SignalingCell SignalingCell modelCellular modelChronicClinicalClinical TrialsCongestive CardiomyopathyCouplingDNA MethylationDNA MethyltransferaseDNA Modification MethylasesDNA Modification MethyltransferasesDNA TherapyDNA-MethyltransferasesDataDependent drinkerDevelopmentDilated CardiomyopathyDisciplineDnmtETOHEchocardiogramEchocardiographyEconomic BurdenEconomicsEtOH abuseEtOH drinkingEtOH useEthanolEthyl AlcoholExhibitsExperimental DesignsFutureGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGene TransferGene Transfer ClinicalGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic InterventionGenetic TranscriptionGoalsGrain AlcoholHealth Care SystemsHeartHeart HypertrophyHeart Muscle CellsHeart failureHeart myocyteHeavy DrinkingHistoryHumanHypermethylationHypertrophyImageImpairmentIn VitroIndividualInterventionIntervention StrategiesIntracellular Communication and SignalingJN KinaseJN kinase kinaseJNKJNK Mitogen-Activated Protein KinasesJNK kinaseJNK-55JNK-activating protein kinaseJNK1JNK1 KinaseJNK1 proteinJNK1A2JNK2JNK2 KinaseJNK2 Stress-Activated Protein KinaseJNK21B1/2JNK2AJNK2AlphaJNK2BJNK2BetaJNKKJun amino-terminal kinase kinaseKinasesKnowledgeLVADLeft VentriclesLeft ventricular structureLinkMAP Kinase 8MAP Kinase 8 GeneMAPK8MAPK8 Mitogen-Activated Protein KinaseMAPK8 geneMAPK9MAPK9 Mitogen-Activated Protein KinaseMAPK9 geneMeasurementMediatingMethylcarbinolMiceMice MammalsMitogen-Activated Protein Kinase 8Mitogen-Activated Protein Kinase 9Modern ManModification MethylasesMolecularMolecular InteractionMorbidityMorbidity - disease rateMurineMusMuscle CellsMyocardial depressionMyocardial dysfunctionMyocytesOrganellesOutcomePRKM8PRKM9PatientsPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPlayPrevalencePreventative strategyPrevention strategyPreventive strategyProgrammed Cell DeathProliferatingProtein PhosphorylationProteinsProteomicsPublic HealthPumpRNA ExpressionRNA SplicingRecording of previous eventsRegulationReportingRisk FactorsRoleSAP Kinase-1SAPK/JNKSAPK1 Mitogen-Activated Protein KinaseSAPK1/JNKSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSERCA2Sarcoplasmic ReticulumSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSignal TransductionSignal Transduction SystemsSignalingSite-Specific DNA-methyltransferaseSocial isolationSplicingStress-Activated Protein Kinase JNK1Stress-Activated Protein Kinase gammaTechniquesTestingTherapeuticTherapeutic InterventionTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransphosphorylasesTransthoracic EchocardiographyVariantVariationalcohol abuseralcohol co-abusealcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol problemalcohol product usealcohol responsealcohol usealcohol-induced heart muscle diseasealcoholic beverage consumptionalcoholic drink intakealcoholic heart muscle diseasebiological adaptation to stressbiological signal transductionc-jun Kinase-2c-jun N-Terminal Kinasecardiac dysfunctioncardiac failurecardiac functioncardiac hypertrophycardiac preservationcardiomyocytecardiovascular disordercausal allelecausal genecausal mutationcausal variantcausative mutationcausative variantcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemicdevelopmentaldrink heavilydrivingdrug discoveryeconomicethanol abuseethanol consumptionethanol drinkingethanol exposedethanol exposureethanol ingestionethanol intakeethanol product useethanol responseethanol useexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolextreme drinkingfunction of the heartgene repair therapygene therapygene-based therapygenetic therapygenomic therapyhazardous alcohol useheart dysfunctionheart functionheart outputheart preservationheart sonographyheavy alcohol usehistoriesimagingin vivoinhibitorinjury to tissueinnovateinnovationinnovativeinsightintervention therapyjun-NH2-Terminal Kinaseleft ventricular assist devicemortalitymouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionp54aSAPKpreventpreventingproblem alcohol useproblem drinkerproblem drinkingproblematic alcohol consumptionproblematic alcohol usepromoterpromotorprospectiveprotein protein interactionreaction; crisisresponseresponse to alcoholresponse to ethanolsevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsocial rolestress responsestress-activated protein kinase 1stress; reactiontherapeutically effectivetissue injurytooltranscription factortranslational opportunitiestranslational potentialtranslational studyuptake
Description preview
Long-term excessive alcohol consumption leads to a significant prevalence of alcoholic cardiomyopathy (ACM) that
is characterized by impaired cardiac function (heart failure, HF) in the absence of other cardiovascular diseases.
During the COVID-19 pandemic, increased alcohol consumption due to social isolation has magnified the serious
problem.…
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