grant
Mechanistic and Structural Insights into Intraflagellar Transport in Leishmania
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025APF-1ATP-Dependent Proteolysis Factor 1Adaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAddressAfrican Sleeping SicknessAfrican TrypanosomiasisAmerican TrypanosomiasisAmerican trypanosomeArchitectureBindingBinding ProteinsBiochemicalBioinformaticsBiologyCell AttachmentCell-Matrix AdhesionsCell-Matrix JunctionChagas DiseaseCharacteristicsChlamydomonas reinhardiiChlamydomonas reinhardtiiChlorophycotaChlorophytaCiliaComplexCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyDataDetectionDevelopmentDiseaseDisorderDyneinDynein ATPaseDynein Adenosine TriphosphataseDynein AdenosinetriphosphataseElectron CryomicroscopyEngineering / ArchitectureFaceFlagellaFoundationsFrequenciesGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGreen AlgaeHMG-20High Mobility Protein 20ImpairmentIn SituIn VitroInsect VectorsKinesinKnowledgeLeishmaniaLeishmaniasisLigand Binding ProteinLigand Binding Protein GeneLinkMeasuresMediatingMicro-tubuleMicrotubule ProteinsMicrotubule-Associated ProteinsMicrotubulesMolecularMolecular InteractionMotilityMotorMovementOrganismOutcomeParasitesPathogenicityPersonsPolymersPolyubiquitinPolyubiquitinationProcessProtein BindingProtein ExportProtein Export PathwayProteinsProteomeProteomicsRecombinant DNA TechnologyRegulationResearchRoleSamplingSouth American TrypanosomiasisStructureSurfaceT bruceiT cruziT. bruceiT. cruziTestingTrainingTravelTrypanosomaTrypanosoma bruceiTrypanosoma brucei bruceiTrypanosoma cruziTrypanosomeTrypanosomiasisUbiquitinWorkadapter proteinanterograde transportbody movementbound proteincartilage link proteincryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydesigndesigningdevelopmentalelectron cryo-tomographyfacesfacialflagellum motilitygenetically engineeredhuman diseasein vivoinfection riskinsightinterdisciplinary approachlink proteinlive cell imagelive cell imaginglive cellular imagelive cellular imagingliving systemmodel organismmonomermultidisciplinary approachmutantnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetparticlepoly-ubiquitinpolymerpolymericreconstitutereconstitutionretrograde transportsegregationsleeping sicknesssocial rolestructural biologytherapeutic target
Description preview
Project Summary
Trypanosomatid parasites are responsible for several human diseases including Chagas disease
(Trypanosoma cruzi), African trypanosomiasis (Trypanosoma brucei), and leishmaniasis (various Leishmania
species). These parasites critically depend on a single flagellum for motility, environmental sensing, and cell
attachment. Disruptions…
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