grant
Mechanisms underlying chromosome segregation
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 22 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Aberrant ChromosomeAneuploidAneuploidyBiochemicalBirth DefectsBudding YeastCancersCell BodyCell CycleCell Cycle ControlCell Cycle RegulationCell Division CycleCell divisionCellsCentromereChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome SegregationChromosome abnormalityChromosomesCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCytogenetic AberrationsCytogenetic AbnormalitiesCytologyDefectDevelopmentDiseaseDisorderEndomycetalesEnsureEukaryotaEukaryoteEvolutionGeneticGenome StabilityGenomic StabilityHereditaryHumanInheritedKinetochoresLeadLoad BearingMalignant CellMalignant NeoplasmsMalignant TumorMicro-tubuleMicrotubulesMiscarriageModern ManOrganismPb elementProcessProteinsSaccharomycetalesSpontaneous abortionTimeWeight BearingWeight-Bearing stateWorkYeastscancer cellchromosomal defectchromosome defectchromosome divisiondaughter celldevelopmentalheavy metal Pbheavy metal leadhuman diseasein vitro Assayliving systemmalignancyneoplasm/cancerpreventpreventing
Description preview
Project Summary
Accurate cell division is essential for the development of all organisms. During each cell cycle, chromosomes
must be precisely partitioned to daughter cells. Defects in chromosome partitioning generate aneuploidy, the
state where entire chromosomes are gained or loss. Aneuploidy is a the most common chromosomal abnormality
in…
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