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Mechanisms of youth-associated blood-borne factors regulating CNS rejuvenation
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 May 2021Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAddressAffectAffinity ChromatographyAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease pathologyAlzheimer's disease riskAlzheimer's disease therapyAlzheimer's pathologyAlzheimer's therapyAlzheimers DementiaAmmon HornAmyloidAmyloid SubstanceAmyloid depositionAmyloidosisBehavior assessmentBloodBlood PlasmaBlood Reticuloendothelial SystemBody SystemBody TissuesBrainBrain DiseasesBrain DisordersBrain Nervous SystemCCL11CCL11 geneCNS Nervous SystemCNS plasticityCell BodyCellsCentral Nervous SystemCognitionCognitiveCognitive deficitsColony-Stimulating FactorsCombined Modality TherapyCornu AmmonisDataDendritic SpinesDependenceDepositDepositionDisease associated microgliaDysfunctionEncephalonEncephalon DiseasesEnvironmentExhibitsExposure toExpression SignatureFunctional disorderGene ExpressionGene Expression ProfileGene TranscriptionGenetic TranscriptionGenetic studyGliosisGoalsHeartHippocampusHortega cellHumanImmuneImmunesImpairmentInjectionsIntracranial CNS DisordersIntracranial Central Nervous System DisordersLearningLesionLinkLiverMGC22554MGI-1 ProteinMediatingMemoryMiceMice MammalsMicrogliaModelingModern ManMolecularMorphologyMultimodal TherapyMultimodal TreatmentMurineMusMuscleMuscle TissueMyelogenousMyeloidMyeloid Cell-Growth InducerNeuraxisNeuroimmuneNeuronal PlasticityOrgan SystemOrganismPancreasPancreaticParabiosisPathologicPathologyPathway interactionsPhenotypePhysiopathologyPlasmaPlasma SerumPopulationPrimary Senile Degenerative DementiaProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationRejuvenationReportingReticuloendothelial System, Serum, PlasmaRibosomesRisk-associated variantRoleSCYA11Tissue Inhibitor of MetalloproteinasesTissuesTranscriptionTransgenic ModelTranslatingWild Type MouseWorkYouthYouth 10-21abnormal brain functionadult neurogenesisaffinity purificationage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentagedaged brainaged miceaged mouseagesaging associated alterationsaging associated changesaging brainaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with agealzheimer riskamyloid diseasebehavioral assessmentbonebrain cellbrain dysfunctionbrain impairmentcellular targetingcentral nervous system plasticitychanges with agecognitive changecognitive defectscognitive functioncognitive performancecombatcombination therapycombined modality treatmentcombined treatmentdendrite spinedevelop therapydysfunctional brainelderly micegene expression patterngene expression signaturegitter cellhepatic body systemhepatic organ systemhippocampalimprovedinnate immune functioninsightintervention developmentliving systemmesogliamicroglial cellmicrogliocytemouse modelmulti-modal therapymulti-modal treatmentmurine modelmuscularnatural agingneural plasticityneurogenesisneuroplasticneuroplasticitynew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnormal agingnormative agingnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyold micepathophysiologypathwayperivascular glial cellprimary degenerative dementiaresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsenile dementia of the Alzheimer typesocial roletherapy developmenttranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtransgenic traittreatment developmenttreatment strategywildtype mouseyouth age
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Project Summary/Abstract: Novel approaches are needed to combat age-associated diseases of the brain,
including Alzheimer’s disease (AD). Aging is the strongest risk factor for AD, yet we lack a detailed mechanistic
understanding connecting normal aging to AD. Emerging data raise the possibility that neural plasticity can be
revitalized in aged…
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