grant
Mechanisms of voice disorders associated with vocal fold atrophy
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 15 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2026Aberrant TissueAcuteAddressAmericanAnatomic SitesAnatomic structuresAnatomyAnnual ReportsArchitectureAreaAsthmaAtrophicAtrophyAutocrine SystemsAutomobile DrivingBenignBiochemicalBiologic PhenomenaBiological FunctionBiological PhenomenaBiological ProcessBody TissuesBone-Derived Transforming Growth FactorBronchial AsthmaCOPDCatabolismCategoriesCausalityCell Communication and SignalingCell SignalingChoristomaChronicChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseClassificationClinicalCo-cultureCocultivationCocultureCoculture TechniquesCommon Rat StrainsComplexDataDevelopmentDiagnostic SpecificityDirect CostsDiseaseDisorderDistalDysfunctionDysphoniaEctopic TissueEmbryonic Muscle CellsEngineering / ArchitectureEnvironmentEtiologyEventFamilyFibroblastsFibrosisFunctional disorderGDF-8GDF8GDF8 geneGene TranscriptionGenesGenetic TranscriptionGrowth Differentiation Factor 8 GeneGrowth and DevelopmentGrowth and Development functionGrowth/Differentiation Factor 8Heterotopic TissueIn SituIn VitroInjuryIntracellular Communication and SignalingInvestigationLaboratoriesLamina PropriaLaryngealLaryngeal DiseasesLaryngeal DisorderLaryngeal MusclesLaryngeal muscle structureLarynxLarynx DiseasesLarynx Head and NeckLesionLiteratureMSTNMacrophageMaintenanceMediatingMediatorMiceMice MammalsMilk Growth FactorModelingMothers Against Decapentaplegic HomologMucosaMucosal TissueMucous MembraneMurineMusMuscleMuscle AtrophyMuscle CellsMuscle DevelopmentMuscle FibersMuscle ParesisMuscle TensionMuscle TissueMuscular AtrophyMuscular DevelopmentMuscular ParesisMuscular TensionMyoblastsMyocytesMyotubesMφNetwork AnalysisNoduleNomenclatureNon-Polyadenylated RNAOutcomePalsyParalysedParesisPathologicPathologyPathway AnalysisPathway interactionsPatientsPhenotypePhonation DisordersPhysiopathologyPlatelet Transforming Growth FactorPlegiaPolypsPrecursor Muscle CellsProcessProtein FamilyProteinsProteomicsRNARNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqRatRats MammalsRattusRecurrent Laryngeal NerveRegulationResistanceRhabdomyocyteRibonucleic AcidRoleSignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSma- and Mad-Related ProteinsSmad ProteinsStandardizationStructureSystemSystematicsTGF BTGF-betaTGF-βTGFbetaTGFβTherapeuticThyroarytenoid MuscleTissuesTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTreatment EfficacyUpregulationVocal FoldVoiceVoice DisordersVoluntary MuscleWorkautocrinebiological signal transductioncausationcell typechronic obstructive pulmonary disorderdevelopmentaldisabilitydisease causationdrivingfallsgrowth-differentiation factor 8in vivoinjuriesinjury responseinnovateinnovationinnovativeinsightinterestintervention efficacylarynx disorderlarynx musclemembermolecular scalemuscle breakdownmuscle degradationmuscle deteriorationmuscle lossmuscle physiologymuscle wastingmuscularmyostatinnerve injuryneural injuryneuromuscularnovelparacrineparalysisparalyticpareticparetic musclepathophysiologypathwaypreventpreventingresistantresponseresponse to injuryskeletal muscle growthsocial roletherapeutic efficacytherapy efficacythyroarytenoideustranscriptome sequencingtranscriptomic sequencingtreatment strategyvocal cordvoice box
Description preview
ABSTRACT
Clinically, atrophy of the intrinsic laryngeal musculature is poorly defined likely related to limited understanding
of fundamental biological processes underlying this complex, aberrant tissue phenotype. This lack of insight
underlies suboptimal therapeutic strategies for these challenging patients. In addition to fundamental…
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