grant
Mechanisms of Translation Control in Humans
Organization UNIVERSITY OF CALIFORNIA BERKELEYLocation BERKELEY, UNITED STATESPosted 7 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AffectAreaBackBehaviorBindingBiochemicalBody TissuesCell BodyCellsCellular immunotherapyDorsumEIF-3EIF3ElementsEngineeringEukaryotaEukaryoteEukaryotic Initiation Factor-3Eukaryotic Peptide Initiation Factor-3FoundationsFutureGenotypeGleanHumanInitiation FactorsInvestigationLifeMHC ReceptorMajor Histocompatibility Complex ReceptorMapsMessenger RNAModern ManMolecularMolecular InteractionNon-Polyadenylated RNAPathway interactionsPeptide Initiation Factor EIF-3Peptide Initiation FactorsPhenotypeProcessProtein BiosynthesisProteinsQuality ControlRNARNA Gene ProductsRibonucleic AcidRibosomal Frame ShiftingRibosomal FrameshiftRibosomal FrameshiftingRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesRoleSpeedStructureT cell regulationT-Cell ActivationT-Cell Antigen ReceptorsT-Cell DevelopmentT-Cell OntogenyT-Cell ReceptorT-Lymphocyte DevelopmentTherapeuticTissuesTrans-Acting FactorsTrans-ActivatorsTransactivatorsTranslation InitiationTranslation Initiation FactorTranslational FrameshiftingTranslational InhibitionTranslational Initiation FactorTranslational RegulationTranslational RepressionTranslationsactivate T cellscell-based immunotherapydesigndesigningdrug discoverydrug-like chemicaldrug-like compounddrug-like moleculeexperimentexperimental researchexperimental studyexperimentshuman diseaseimmune cell therapyimprovedinsightinterestmRNApathwaypolypeptideprotein synthesissmall moleculesocial roletranslation
Description preview
ABSTRACT
Protein synthesis, or translation, connects genotype to phenotype in all forms of life. The Cate lab has a
longstanding interest in the mechanisms of protein synthesis, from universal principles gleaned from bacterial
translation to the basis of translation regulation in humans. This application tackles fundamental questions
about how…
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