grant
Mechanisms of spatiotemporal signaling by GPCRs
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253'5'-cyclic ester of AMPAdenosineAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdenosine, cyclic 3',5'-(hydrogen phosphate)Adrenergic ReceptorAdrenoceptorsAffectAgonistAnimalsAreaAscorbic AcidAssayBehaviorBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBiologyCaliforniaCardiovascular PhysiologyCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell membraneCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelCoupledCouplingCyclic AMPCyclic AMP-Dependent Protein KinasesCytoplasmic MembraneDiseaseDisorderEndocrineEndocytosisEndosomesEpinephrine ReceptorsFamilyG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingG-Protein-Coupled ReceptorsG-ProteinsGPCRGPCR SignalingGTP-Binding ProteinsGTP-Regulatory ProteinsGoalsGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHemi-MyeloperoxidaseImaging ProceduresImaging TechnicsImaging TechniquesIn VitroIntegral Membrane ProteinIntracellular Communication and SignalingIntrinsic Membrane ProteinKnowledgeLabelLigand BindingLigandsLinkLocationMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembraneMentorsMentorshipModelingMolecularMutateMyeloperoxidaseOrganism-Level ProcessOrganismal ProcessOutcomeOutputPACAP type II receptorPACAPR-2 proteinPKAPathway interactionsPerceptionPeroxidasesPhasePhosphorylation SitePhysiologic ProcessesPhysiological ProcessesPlasma MembranePolypeptide HormonesPostdocPostdoctoral FellowProtein BiochemistryProtein Kinase AProtein translocationProtein/Amino Acid BiochemistryProteinsProteomeProteomicsRDC1 GeneReceptor ActivationReceptor ProteinReceptor SignalingReceptosomesRecyclingRegulationResearchResearch AssociateResearch ResourcesResourcesSan FranciscoSensorySignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSortingSubcellular ProcessSystemTIRF MicroscopyTherapeuticTotal Internal Reflection FluorescentTotal Internal Reflection Fluorescent MicroscopyTrainingTransmembrane ProteinTransmembrane Protein GeneTransmembrane Protein TransportUniversitiesVIP ReceptorsVIP-1 receptorVIP1 receptorVIPR GeneVIPR1VIPR1 geneVIPR1 proteinVIT CVPAC1 receptorVasoactive Intestinal Peptide Receptor 1 GeneVasoactive Intestinal Peptide ReceptorsVitamin CWorkadenoreceptoradenosine 3'5' monophosphatearrestin Bbeta-arrestinbiological signal transductioncAMPcAMP-Dependent Protein Kinasescardiovascular functiondesigndesigningexperienceexperimentexperimental researchexperimental studyexperimentsfrontierinsightmembrane structurenovelpathwaypituitary adenylate cyclase-activating peptide receptor, type IIplasmalemmapost-docpost-doctoralpost-doctoral traineeprotein activationreceptorreceptor internalizationreceptor recyclingreconstitutereconstitutionresearch associatesresponseskillsspatial and temporalspatial temporalspatiotemporaltherapeutic targettooltraffickingtraining opportunityvasoactive intestinal peptide receptor 1β-arrestin
Description preview
Project Summary
G protein-coupled receptors (GPCRs) comprise the largest family of signaling receptors in animals, and as such,
they represent an important class of therapeutic targets. Following ligand binding and G protein activation at the
plasma membrane, GPCRs undergo regulated endocytosis and sorting for recycling or degradation.…
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