grant
Mechanisms of Primary Cilium Assembly and Disassembly
NIHUS FederalResearch GrantFY2025BiochemicalBiogenesisBody TissuesCRISPRCRISPR/Cas systemCancersCell BodyCell Communication and SignalingCell ComponentsCell CycleCell Division CycleCell FunctionCell PhysiologyCell ProcessCell SignalingCell StructureCellsCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessCellular StructuresCellular biologyCentrosomeChildhoodCiliaCiliary ProcessClustered Regularly Interspaced Short Palindromic RepeatsCommunitiesDefectDevelopmentDiagnosisDiseaseDisorderGoalsHealthHereditaryHuman FigureHuman bodyInheritedIntracellular Communication and SignalingLinkMalignant NeoplasmsMalignant TumorMediatingMediatorMembraneMethodsMicroscopyMolecularMolecular AnalysisOrganellesOrigin of LifePathologyPathway interactionsPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesProliferatingProtein TraffickingProteinsResearchRoleScreening procedureSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructure of ciliary processesSubcellular ProcessSurfaceSyndromeTissuesbiological signal transductioncell biologycell growthcell typeciliogenesisciliopathycilium biogenesisdevelopmentalfunctional genomicsgain of functiongenome scalegenome-widegenomewidegenomic toolsimprovedinnovateinnovationinnovativeinsightloss of functionmalignancymembrane structureneoplasm/cancernovelpathwaypediatricprogramsprotein transportscreeningscreening toolsscreeningssocial roletooltumoruncontrolled cell growth
Description preview
PROJECT SUMMARY
Cilia protrude from the surface of most cells in the human body and can be traced to the last eukaryotic
common ancestor. Despite their near ubiquity, the functions of non-motile primary cilia were largely unknown
until two foundational discoveries: first, select signaling pathways depend upon and localize to primary cilia, and…
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