grant
Mechanisms of polarized protein sorting in AP-1B-deficient epithelia
Organization WAYNE STATE UNIVERSITYLocation DETROIT, UNITED STATESPosted 1 Aug 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Adaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAdhesion MoleculeAlimentary CanalApicalArchitectureAutoregulationBody TissuesCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell membraneCell surfaceCellsClathrin AdaptorsClathrin Assembly ProteinsClathrin-Associated AdaptorsClathrin-Associated ProteinsCytoplasmic MembraneDiagnosisDigestive TractDiseaseDisorderEndosomesEngineering / ArchitectureEpithelial CellsEpithelial PhysiologyEpitheliumFoundationsFunding MechanismsFutureGI TractGP330 AntigenGastrointestinal TractGastrointestinal tract structureGlycoprotein 330GoalsHeyman's Nephritis Antigen GP330Heymann Nephritis Antigen GP330HomeostasisIndividualKidneyKidney Urinary SystemKnowledgeLDL-Receptor Related Protein 2LRP-2LRP-2 ReceptorLiquid substanceLiverLow-Density Lipoprotein Receptor-Related Protein-2MaintenanceMediatingMediatorMegalinMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMissionModelingMolecularNIGMSNational Institute of General Medical SciencesNephritis Antigen GP 330Nervous SystemNeurologic Body SystemNeurologic Organ SystemOrganOuter pigmented layer of retinaPathologyPathway interactionsPhysiologicPhysiologicalPhysiological HomeostasisPigment cell layer of retinaPigmented layer of retinaPlasma MembraneProcessProtein SortingsProteinsProteomicsProximal Kidney TubulesReceptor ProteinReceptosomesRecyclingRenal Glycoprotein GP330ResearchRetinal Pigment EpitheliumRetinal pigment epithelial cellsRoleSkinSortingStructureStructure of retinal pigment epitheliumSurfaceSurface ProteinsTestingTimeTissuesTraining Programsadapter proteinalimentary tractcell adhesion proteindigestive canaldisease preventiondisorder preventionflexibilityflexiblefluidgp 330hepatic body systemhepatic organ systemkidney epithelial cellliquidnovelpathwayplasmalemmaprogramsreceptorrenalrenal proximal tubulesocial rolesorting nexinssynaptobrevintraffickingvesicle-associated membrane protein
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Project Summary
Epithelial cells carry out secretory and absorptive functions that require the polarized distribution of
transporters, receptors and adhesion molecules at the apical and basolateral plasma membranes. Acquisition
and maintenance of apical-basolateral polarity involves sorting of plasma membrane proteins along the
biosynthetic and…
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