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Mechanisms of photoreceptor protein transport and compartmentalization

Organization UPSTATE MEDICAL UNIVERSITYLocation SYRACUSE, UNITED STATESPosted 1 Sept 2007Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025AddressApicalArrestinsAutomobile DrivingBiochemicalBiologicalBiophysical ProcessBlindnessCell BodyCell Communication and SignalingCell SignalingCellsChaperoneChargeColoring AgentsConeCytoplasmDarknessDefectDiminished VisionDiseaseDisorderDyesDysfunctionElectrostaticsExclusionEyeEyeballFeedbackFluorescenceFluorescence AnisotropyFluorescence Light MicroscopyFluorescence MicroscopyFunctional ImagingFunctional disorderFundingGoalsHomoHydrophobicityImaging DeviceImaging InstrumentImaging ToolIn VitroIntracellular Communication and SignalingKnowledgeLightLight Signal TransductionLipid BindingLipidsLocationLow VisionMapsMeasuresMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMicroscopyModificationMolecularMolecular ChaperonesNerve CellsNerve UnitNeural CellNeurocyteNeuronsPartial SightPhotonsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhototransductionPhysiologic ImagingPhysiopathologyPreparationProcessPropertyProtein TraffickingProteinsReduced VisionReportingResolutionRetinaRetinal DegenerationRetinal PhotoreceptorsRetinal S-AntigenRodRod PhotoreceptorsRods and ConesRoleSightSignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSliceSubnormal VisionSurfaceSurface ProteinsSynapsesSynapticTimeTransgenic OrganismsTransmissionVertebrate PhotoreceptorsVisionVisualVisual ReceptorVisual TransductionVisual impairmentWorkXenopusXenopus sp.analytical ultracentrifugationarrestin 1biologicbiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical mechanismbiophysical parametersbiophysical propertiesciliogenesiscilium biogenesisclawed frogdegenerative retina diseasesdesigndesigningdrivingdriving forceelectric fieldfluorescence imagingfluorescent imaginggene editing methodgene editing methodologygene editing strategygene editing techniquesgene-editing approachimaging approachimaging based approachin vivoinsightlipid boundmembrane structureneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologyphotoreceptor degenerationphysical separationphysiological imagingpreparationsprotein distributionprotein foldingprotein transportresolutionsresponserestore sightrestore visionretina degenerationretinal degenerativeretinal degenerative diseasesretinal rodsrod cellsegregationsight restorationsocial rolesynapsetraffickingtransgenictransmission processvision impairmentvision lossvision restorationvisual dysfunctionvisual functionvisual lossvisual phototransductionvisually impairedvoltage

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Description preview

PROJECT SUMMARY/ABSTRACT
The objectives of this proposal are to determine the mechanisms of photoreceptor protein

compartmentalization. Retinal photoreceptors are polarized neurons whose major functions,

include receiving and transmitting signals, are compartmentalized into discrete subcellular

domains. Compartmentalization is critical for normal…

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Mechanisms of photoreceptor protein transport and compartmentalization β€” UPSTATE MEDICAL UNIVERSITY | UNITED STATES | Se | Dev Procure