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Mechanisms of oxygen off-loading from red blood cells in murine models of human disease
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 8 Jan 2022Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAQP1 geneActive Follow-upAddressAffectAgeAgingAirAlveolarAmino Acid SequenceAnimal ExperimentsAquaporinsAssayBioassayBiological AssayBiologyBiophysicsBloodBlood Plasma CellBlood Reticuloendothelial SystemBlood capillariesBlood erythrocyteBody TissuesCO2COVID-19CV-19Carbon DioxideCarbonic AnhydrideCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Membrane LipidsCell Membrane ProteinsCell ShapeCell SizeCell membraneCellsCollaborationsComplexConsumptionCoronavirus Infectious Disease 2019Cytoplasmic MembraneDNA mutationDataData AnalysesData AnalysisDiffusionDiseaseDisorderDissociationErythrocytesErythrocyticExerciseExhibitsGasesGene ModifiedGeneticGenetic ChangeGenetic PolymorphismGenetic defectGenetic mutationGenomicsGenotypeGeometryGoalsGrantHealthHeart VascularHeart failureHematologyHemoglobinHumanImpairmentIndirect CalorimetryInterdisciplinary ResearchInterdisciplinary StudyInvestigatorsIon ChannelIonic ChannelsKO miceKineticsKnock-outKnock-out MiceKnockoutKnockout MiceLaboratoriesLeannessLibrariesLifeLipidsLiquid substanceLungLung DiseasesLung Respiratory SystemMarrow erythrocyteMath ModelsMeasuresMembraneMembrane ChannelsMembrane LipidsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolicMiceMice MammalsMissense MutationModern ManMolecularMolecular Dynamics SimulationMouse StrainsMovementMultidisciplinary CollaborationMultidisciplinary ResearchMurineMusMuscleMuscle TissueMutationMutation AnalysisNatureNull MouseO elementO2 elementOocytesOvocytesOxygenOxyhemoglobinPathway interactionsPatientsPerformancePermeabilityPlasma CellsPlasma MembranePlasmacytesPlayPrimary Protein StructureProcessProteinsProteomicsProtocolProtocols documentationPulmonary DiseasesPulmonary DisorderReactionRed Blood CellsRed CellResearchResearch PersonnelResearchersResistanceRespiration CalorimetryRhesusRoleRunningSepsisSodium DithioniteSpeedStructural BiologistSurface ProteinsSystems BiologyTestingThinkingThinnessTissuesVascular DiseasesVascular DisorderWater Channel ProteinsWorkactive followupagesanimal experimentaquaporin 1biophysical foundationbiophysical principlesbiophysical sciencesblood corpusclesblood vessel disorderbody movementcapillarycardiac failurecell dimensioncell typecirculatory systemcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19data interpretationdiffuseddiffusesdiffusingdiffusionsdisease modeldisease of the lungdisorder modeldisorder of the lungexercise capacityexperimentexperimental animalexperimental animalsexperimental researchexperimental studyexperimentsextracellularfallsfluidfollow upfollow-upfollowed upfollowupgene modificationgenetically modifiedgenome mutationhuman diseasehuman modelhypoperfusionimprovedindelinhibitorinsertion/deletioninsertion/deletion mutationinsightlipidomicsliquidlung disordermathematic modelmathematical modelmathematical modelingmembrane structuremissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmodel of humanmolecular dynamicsmouse modelmurine modelmuscularmutantnovelpathwayplasmalemmaplasmocytepolymorphismprematureprematurityprotein sequencepublic health relevancepulmonaryresistantsocial rolethoughtsthree dimensionaltooltreadmilluptakevascular dysfunctionvasculopathywater channelwater transporter
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Description preview
Red blood cells (RBCs) play a vital role in gas transport—carrying O2 from the alveolar air to systemic tissues,
and CO2 in the opposite direction. Their task is central to many diseases of major public-health relevance, in-
cluding including heart failure, pulmonary disease (including COVID-19), vascular disease, and sepsis (hy-
poperfusion). An…
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