grant
Mechanisms of osmosensing in GI enteroendocrine cells
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202521+ years old3'5'-cyclic ester of AMP5-HT5-Hydroxytryptamine5HTAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AdultAdult HumanAffectAlimentary CanalAnionsAutomobile DrivingBlood SerumCCKCalciumCalcium Ion SignalingCalcium SignalingCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell modelCell-to-Cell InteractionCellsCellular modelChemicalsCholecystokininClinical TreatmentCollaborationsColonCyclic AMPCytoplasmDataDiarrheaDietDiet ModificationDietary ComponentDietary ModificationsDigestive TractDoctor of PhilosophyEC CellEatingElectrophysiologyElectrophysiology (science)EnteramineEnterochromaffinEnterochromaffin CellsEnteroendocrine CellEnvironmentEpithelial CellsEpitheliumExhibitsExposure toFermentationFoodFood IntakeFutureGI TractGLP-1Gastrointestinal DiseasesGastrointestinal MotilityGastrointestinal PhysiologyGastrointestinal TractGastrointestinal tract structureGlp-1GoalsGut EpitheliumHippophaineHydrogen OxideIngestionIntracellular Communication and SignalingIrritable Bowel SyndromeIrritable ColonKidneyKidney TubulesKidney Urinary SystemKnowledgeL CellsLearningLiteratureLocationMiceMice MammalsMolecularMonosaccharidesMotilityMucous ColitisMurineMusNeurophysiology / ElectrophysiologyNeurotensinNutrientOligoOligonucleotidesOralOrganoidsOsmolalitiesOsmolar ConcentrationOsmolarityOsmosisPainPainfulPancreozyminPathway interactionsPatientsPh.D.PhDPhysiciansPhysiologicPhysiologicalPhysiologyPiezo 2Piezo 2 ion channelPiezo2PopulationProcessProteinsReceptor ActivationReceptor CellReceptor ProteinRegulationRenal tubule structureResearch ActivityRoleScientistSensorySerotoninSerumSignal TransductionSignal Transduction PathwaySignal Transduction SystemsSignalingSignaling MoleculeSmall IntestinesSpecific qualifier valueSpecifiedSpeedStimulusStomachSurgeonSymptomsTechniquesTestingTherapeuticTimeTrainingTransgenic OrganismsTubularTubular formationUropancreozyminVisceralWaterWorkadenosine 3'5' monophosphateadulthoodalimentary tractalleviate symptomameliorating symptomantagonismantagonistbiological signal transductioncAMPcell transductioncellular transductionclinical interventionclinical relevanceclinical therapyclinical trainingclinically relevantdecrease symptomdiet alterationdietary alterationdietsdigestive canaldisabilitydisorders of gut-brain interactiondrivingelectrophysiologicalextracellularfewer symptomsgastricgastrointestinalgastrointestinal disordergastrointestinal epitheliumghrelinglucagon-like peptide 1ingestinnovateinnovationinnovativeinsightlive cell imagelive cell imaginglive cellular imagelive cellular imagingmechanical cuemechanical forcemechanical signaloligospathwaypolyolreceptorreduce symptomsrelieves symptomsrenalrenal tubuleresponsesensorskillssmall bowelsocial rolespastic colonsymptom alleviationsymptom reductionsymptom relieftransduced cellstransgenictrial regimentrial treatment
Description preview
PROJECT SUMMARY/ABSTRACT
The gastrointestinal (GI) epithelium directly senses components of foods we eat, which contain a variety of
nutritive and non-nutritive stimuli. These stimuli come from foods with a range of osmolality from zero (water) to
>1,500 mmol/kg-H2O for some of the saltiest foods. GI epithelial cells are not only first to sense…
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