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Mechanisms of Nucleic Acid Immunogenicity
Organization EMORY UNIVERSITYLocation ATLANTA, UNITED STATESPosted 1 Mar 2022Deadline 31 Jan 2026 ⚠️
NIHUS FederalResearch GrantFY2025AdenoviridaeAdenovirusesAlternate SplicingAlternative RNA SplicingAlternative SplicingAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryArchitectureAssayAutoimmune DiseasesAwardBase PairingBindingBioassayBiochemicalBiological AgentBiological AssayBiological ProductsCalorimetryCareer CounselingCareer GuidanceCellular StressCellular Stress ResponseChalkChronic DiseaseChronic IllnessComplexConsultationsCryo-electron MicroscopyCryoelectron MicroscopyCrystallographiesCrystallographyDAI Protein KinaseDSRNA-Dep Protein KinaseDevelopment PlansDevelopment and ResearchDevicesDiseaseDisorderDouble Stranded RNA-Dependent eIF-2 alpha Protein KinaseDouble-Stranded RNAEIF2AK1EXTMREducational process of instructingElectron CryomicroscopyElementsEndoribonucleasesEngineering / ArchitectureEukaryotic Initiation Factor 2alpha KinaseEvaluationExtramuralExtramural ActivitiesFluorescence PolarizationFoundationsFunctional RNAFundingFutureGene TranscriptionGenetic DiversityGenetic TranscriptionGenetic VariationGenetics-MutagenesisHIV-1HIV-IHIV1Heme Controlled RepressorHeme-Controlled InhibitorHeme-Controlled Translational RepressorHeme-Regulated eIF-2alpha KinaseHemin Controlled RepressorHemin-Controlled Translational RepressorHost FactorHost Factor ProteinHumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1Human poliovirusIFNImmuneImmune responseImmunesIn VitroInfectionInflammatoryInnate Immune ResponseInnate ImmunityInstitutionIntegration Host FactorsInterferon-Induced Double-Stranded RNA-Activated Protein KinaseInterferon-Inducible Double Stranded RNA Dependent Protein KinaseInterferon-Inducible RNA-Dependent Protein KinaseInterferon-Inducible elF2Alpha KinaseInterferonsInternationalInterviewIntramural ResearchInvestigatorsIsoformsJobsKinasesKnowledgeLeadershipLentivirinaeLentivirusLinkMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMentorsMessenger RNAModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutagenesisMutagenesis Molecular BiologyNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthNative ImmunityNatural ImmunityNon-Polyadenylated RNANon-Specific ImmunityNoncoding RNANonspecific ImmunityNontranslated RNANucleic AcidsOccupational GuidanceOccupationsP1/eIF2A Protein KinaseP68 Protein KinasePRKRPRKR genePathway interactionsPhasePhosphatesPhosphotransferase GenePhosphotransferasesPolio VirusPoliovirusPositionPositioning AttributePostbaccalaureatePredispositionPrincipal InvestigatorProfessional PositionsProtein Binding DomainProtein Binding MotifProtein BiochemistryProtein InhibitionProtein IsoformsProtein Kinase PKRProtein-Protein Interaction DomainProtein/Amino Acid BiochemistryProteinsPublic HealthPutative RNA-Binding RegionR & DR&DRNARNA Activated Protein KinaseRNA Binding DomainRNA DecayRNA ExpressionRNA Gene ProductsRNA NucleasesRNA Recognition MotifRNA SplicingRNA endonucleaseRNA-Dependent Protein KinaseRNP DomainRNP MotifRNP-1 SignatureRNaseRegulationResearchResearch PersonnelResearchersResistanceRibonuclease Family ProteinRibonucleasesRibonucleic AcidRisk FactorsScientistSecureSelf-Phosphorylating Protein KinaseSingle Crystal DiffractionSiteSolidSpinal ColumnSpineSplicingStressStructureSusceptibilityTIK KinaseTeachingTestingTrainingTranscriptTranscriptionTranslation InitiationTranslational InhibitionTranslational RepressionTranslationsTransphosphorylasesUnited States National Institutes of HealthUntranslated RNAVertebral columnViralViral ActivityViral DiseasesViral FunctionViral Gene ProductsViral Gene ProteinsViral GenomeViral PhysiologyViral ProteinsVirusVirus DiseasesVirus InhibitorsVirus ReplicationVocational CounselingVocational GuidanceWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyarms raceautoimmune conditionautoimmune disorderautoimmunity diseasebackbonebiologicsbiopharmaceuticalbiophysical analysisbiophysical approachesbiophysical methodologybiophysical methodsbiophysical studiesbiophysical techniquesbiotherapeutic agentcareer counselorcareer developmentcell stresschronic disorderconformationconformationalconformational stateconformationallyconformationsconsultationcostcrosslinkcryo-EMcryoEMcryogenic electron microscopydesigndesigningdsRNAdsRNA-Activated InhibitoreIF-2 KinaseeIF-2 Recycling Factor eRFeIF-2alpha Kinaseexecutive coachinghost responseimmune system responseimmunogenicityimmunoresponseinfectious disease treatmentinhibit proteininhibit proteinsinhibitorinorganic phosphateinsightmRNAnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnoncodingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachnucleaseoligoadenylatep65 Kinasep68 Kinasepathwayphosphodiesterpoliomyelitis viruspostbacpostbaccprotein expressionprotein functionprotein inhibitionsprotein kinase Rprotein protein interactionreconstitutereconstitutionresearch and developmentresistantsingle-molecule FRETsingle-molecule fluorescence resonance energy transferskill acquisitionskill developmentskillssmFRETstructural biologytenure processtenure tracktooltranslationtranslation factortriphosphatetripolyphosphateviral RNAviral infectionviral inhibitorviral multiplicationviral replicationvirus RNAvirus genomevirus infectionvirus multiplicationvirus proteinvirus-induced disease
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Project Summary/Abstract
The proposed research seeks to elucidate the structural and mechanistic basis of RNA-dependent innate
immune antiviral proteins regulation that stop translation to curb viral infection. The proposal employs a
synergistic combination of structural biology (X-ray crystallography, cryo-EM), biochemical analyses (kinase,
RNA…
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