grant
Mechanisms of Nuclear Egress in Gamma-herpesviruses
Organization TUFTS UNIVERSITY BOSTONLocation BOSTON, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026Africa South of the SaharaAssayAujeszky's Disease VirusAujeszkys Disease VirusBindingBioassayBiological AssayBiologyBurkitt HerpesvirusBurkitt Lymphoma VirusCancer CauseCancer Causing AgentsCancer EtiologyCancersCapsidCarcinogensCell BodyCell NucleusCellsComplexCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyCytoplasmDNADeoxyribonucleic AcidDevelopmentDimensionsDistantDouble-Stranded DNAEB virusEBVEffectivenessElectron CryomicroscopyEndemic DiseasesEnsureEpstein Barr VirusEventGeneHomologGenetics-MutagenesisGenomeGeometryGoalsHHV-4HHV-8HHV4HHV8HSV-1HSV1Herpes Simplex Type 1Herpes Simplex Virus 1Herpes Simplex Virus Type 1Herpes infectionHerpesviridaeHerpesviridae InfectionsHerpesviridae diseaseHerpesvirus 1Herpesvirus 1 (alpha), SuidHerpesvirus InfectionsHerpesvirus SuisHerpesvirusesHomologHomologous GeneHomologueHumanHuman Herpesvirus 4Human Herpesvirus 8In VitroInfectionInfectious Mononucleosis VirusKSHVKaposi SarcomaKaposi Sarcoma-Associated Herpes VirusKaposi Sarcoma-Associated HerpesvirusKaposi sarcoma associated virusKaposi sarcoma herpes virusKaposi's SarcomaKaposi's sarcoma (KS)-associated herpesvirusLymphoproliferative DisordersLytic CycleLytic InfectionLytic PhaseMalignant NeoplasmsMalignant TumorMeasuresMediatingMembraneModelingModern ManMolecular InteractionMulticentric Angiofollicular Lymphoid HyperplasiaMulticentric Castleman's DiseaseMultiple Hemorrhagic SarcomaMutagenesisMutagenesis Molecular BiologyMutation AnalysisNuclearNuclear EnvelopeNuclear MembraneNuclear PoreNucleusOncogenicOncogenic VirusesOncogensPlayProcessProductionProteinsPseudorabies virusRecombinantsRoleRunningScientistSeroprevalencesSingle Crystal DiffractionStructureSub-Saharan AfricaSubsaharan AfricaSuid Herpesvirus 1Swine Herpesvirus 1TestingTherapeuticTimeTumor VirusesVesicleViralViral Gene ProductsViral Gene ProteinsViral ProteinsVirionVirusVirus ParticleVirus ReplicationVirus-HHV8VisualizationWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographycareercryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydesigndesigningdevelopmentaldimerds-DNAdsDNAelectron cryo-tomographygamma-herpesvirusgammaherpesvirusherpes simplex iherpes simplex-1herpes virusimprovedin vivoinnovateinnovationinnovativeinsightkaposi's sarcoma herpesviruskaposi's sarcoma-associated human herpesviruslatent infectionlymphoproliferative diseasemad itch virusmalignancymembrane structuremulticastleman's diseasesmutantneoplasm/cancerneurotropiconcogenic agentoncogenic tumor virusoverexpressoverexpressionprimary effusion lymphomaprotein complexskillssocial roletherapeutic agent developmenttherapeutic developmenttherapeutic targettomographyviral multiplicationviral replicationvirologyvirus multiplicationvirus proteinγ-herpesvirus
Description preview
PROJECT SUMMARY/ABSTRACT
Kaposi’s sarcoma-associated herpesvirus (KSHV) is an enveloped, double-stranded-DNA g-herpesvirus and
class I carcinogen. KSHV is the causative agent of Kaposi’s sarcoma, primary effusion lymphomas, and
multicentric Castleman’s disease. In sub-Saharan Africa, it has seroprevalence rates as high as 80% and causes
endemic…
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