grant
Mechanisms of mRNA Recruitment into Stress Granules
NIHUS FederalResearch GrantFY20254-Thiouridine4-thio-uridineATP-protein phosphotransferaseAgingAppearanceAreaAutomobile DrivingAuxinsBinding ProteinsBiogenesisBioinformaticsBiological FunctionBiological ProcessBiologyCancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular RegulationCore ProteinCoupledCytoplasmCytoplasmic GranulesDNA Polymerase IIDNA Polymerase epsilonDNA-Dependent DNA Polymerase IIDNA-Dependent RNA Polymerase IIDataDiseaseDisorderElementsEukaryotic Initiation FactorsEukaryotic Peptide Initiation FactorsEukaryotic Translation Initiation FactorsFoundationsG3BPG3BP1G3BP1 geneGene TranscriptionGenesGenetic TranscriptionGoalsHeterogeneous-Nuclear RibonucleoproteinsHuman Cell LineIF2 ProteinIndividualInformoferInitiation Factor-2Intracellular Communication and SignalingInvestigationKinase Family GeneKnowledgeLabelLigand Binding ProteinLigand Binding Protein GeneLinkMalignant NeoplasmsMalignant TumorMessenger RNAModelingModificationNerve DegenerationNeuron DegenerationNon-Polyadenylated RNANonsense CodonNuclearNuclear ExportNuclear RNAOrigin of LifeOxidative StressPeptide Initiation Factor 2Peptide Initiation Factor IF-2PhasePhysical condensationPlayPol IIPoly(A) TailPopulationPremature Stop CodonProcessProkaryotic Initiation Factor-2Protein BindingProtein BiosynthesisProtein KinaseQuality ControlRNARNA ExpressionRNA Gene ProductsRNA Polymerase BRNA Polymerase IIRNA-Binding ProteinsRegulationReportingResearchRibonucleic AcidRibonucleoproteinsRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleScanningSignal TransductionSignal Transduction SystemsSignalingStressSubcellular ProcessSystemTestingTherapeuticThiouridineTimeTranscriptTranscriptionTranslation InitiationTranslational Initiation Factor 2TranslationsValidationViral DiseasesVirus DiseasesVisualizationbiological adaptation to stressbiological signal transductionbound proteincell growth regulationcondensationdrivingenvironmental stressesenvironmental stressorexperienceexperimentexperimental researchexperimental studyexperimentsglobal gene expressionglobal transcription profileglycogen synthase a kinasegranulehnRNPhydroxyalkyl protein kinaseinfB Gene ProductinfB ProteininhibitorinsightmRNAmRNA Exportmalignancyneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoptic imagingoptical imagingphosphorylase b kinase kinasepreventpreventingprogramsprotein Eprotein synthesisreaction; crisisrecruitresponsesingle moleculesocial rolestress granulestress responsestress; reactiontooltranscriptometranslationvalidationsviral infectionvirus infectionvirus-induced disease
Description preview
ABSTRACT
The integrated stress response (ISR) is an evolutionarily conserved signaling network that is activated
in response to environmental stress and functions to support stress adaptation. A key part of the ISR is the
stalling of global translation while allowing for the preferential translation of stress response factors. Upon
stalling of…
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