grant
Mechanisms of mitochondria-driven hepatocyte injury
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Acid FastAcid Fast BacillaeAcid Fast Bacillae Staining MethodAcuteAddressAdverse ExperienceAdverse eventAnimal ModelAnimal Models and Related StudiesAnimalsAreaAssayAutomobile DrivingBindingBioassayBiologic ModelsBiological AssayBiological ModelsBiologyBlood SerumCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell Communication and SignalingCell DeathCell SignalingCessation of lifeClinicalCouplingDataDeathDietDiseaseDisorderDouble-Stranded RNAEF Hand MotifsEF HandsEF-Hand Calcium-Binding MotifEF-Hand DomainEndoplasmic ReticulumEnzyme GeneEnzymesErgastoplasmFamily memberFatty AcidsGene variantGenesGeneticGenetic studyHeart VascularHepaticHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatocyteHexadecanoatesHumanHuman GeneticsHuman PathologyImageIn VitroIncidenceInflammationInflammatory ResponseInjuryInjury to LiverInnate ImmunityIntracellular Communication and SignalingInvestigatorsIsotopesKO miceKnock-out MiceKnockout MiceLinkLiverLiver CellsLiver diseasesMeasuresMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsMitochondriaModel SystemModern ManMolecular InteractionMurineMusNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNull MouseNutrientObesityOrganOrganoidsOutcomeOuter Mitochondrial MembraneOvernutritionPalmitatesPathologicPathologyPathway interactionsPhenotypePopulationPredispositionPrevalenceProcessProteinsResearch PersonnelResearchersResistanceRespirationRiskSeriesSerumSignal TransductionSignal Transduction SystemsSignalingSteatohepatitisSusceptibilityTechniquesTestingTherapeuticThesaurismosisTransducersTriacylglycerolTriglyceridesadiposityallelic variantbiological adaptation to stressbiological signal transductioncardiovascular disordercardiovascular riskcardiovascular risk factorcirculatory systemcorpulencedietsdrivingdrug developmentdsRNAexperienceexperimentexperimental researchexperimental studyexperimentsfat metabolismfatty acid oxidationgenetic analysisgenetic variantgenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationgenomic varianthepatic body systemhepatic damagehepatic diseasehepatic inflammationhepatic injuryhepatic metabolismhepatic organ systemhepatocyte injuryhepatopathyimagingin vivoinflamed liverinjuriesinnovateinnovationinnovativelipid metabolismliver damageliver disorderliver inflammationliver injuryliver metabolismloss of functionmetabolic phenotypemetabolism disordermetabolism measurementmetabolomicsmetabonomicsmetabotypemitochondrialmodel of animalmouse modelmurine modelnecrocytosisnovelobesity-promoting dietobesogenic Western-style dietobesogenic dietobesogenic high fat dietobesogenic western dietoxidationpathwaypreventpreventingpro-obesity dietracial diversityracially diversereaction; crisisrecruitresistantrespiratory mechanismsensorstress responsestress; reactiontherapeutic targettooltranscriptomicsuptakevoltage clamp
Description preview
PROJECT SUMMARY
The prevalence of metabolic disease is growing rapidly, driven predominantly by increasing incidence of obesity
and metabolic-associated steatohepatitis (MASH). However, there are very limited therapies for treating liver
injury, placing these as a growing area of unmet clinical need. One therapeutic approach for metabolic diseases…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click