grant
Mechanisms of Manganese Neurotoxicity
Organization PURDUE UNIVERSITYLocation WEST LAFAYETTE, UNITED STATESPosted 1 May 2001Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY2025AKTAcuteAddressAdverse effectsAgeAkt proteinAntioncogene Protein p53AstrocytesAstrocytusAstrogliaBiologic ModelsBiologicalBiological ModelsC elegansC. elegansC.elegansCNS Nervous SystemCaenorhabditis elegansCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCellular Tumor Antigen P53Central Nervous SystemChronicComplexDataDoseEnvironmental ExposureEnzyme GeneEnzymesEpistasisEpistatic DeviationExperimental DesignsExperimental ModelsFundingGene ModifiedGeneticGenetic EpistasisHealthHumanHumulin RIndividualInsulinInsulin-Like Growth FactorsInteraction DeviationIntoxicationIntracellular Communication and SignalingInvestigationKinasesKnowledgeLifeLinkManganeseMeasurementMetabolicMetabolic PathwayMn elementModel SystemModelingModern ManMorbidityMorbidity - disease rateNerve CellsNerve Transmitter SubstancesNerve UnitNervous System DiseasesNervous System DisorderNetwork AnalysisNeural CellNeural Stem CellNeuraxisNeurocyteNeurologicNeurologic DisordersNeurologic outcomeNeurologicalNeurological DisordersNeurological outcomeNeuronsNeurotransmittersNovolin RNutritionalOncoprotein p53P53PathologicPathway AnalysisPathway interactionsPhenotypePhosphatesPhosphoprotein P53Phosphoprotein pp53Phosphotransferase GenePhosphotransferasesPopulationProtein Kinase BProtein TP53Proto-Oncogene Proteins c-aktRAC-PK proteinRegular InsulinReportingResearchRiskRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSilent Mating Type Information Regulator 2-like ProteinsSir2-like ProteinsSirtuinsSomatomedinsSulfation FactorSystemTP53TP53 geneTRP53TestingToxic effectToxicitiesTransgenic OrganismsTranslationsTransphosphorylasesTumor Protein p53Tumor Protein p53 Geneaged brainagesaging brainastrocytic gliabehavior outcomebehavior responsebehavioral outcomebehavioral responsebiologicbiological signal transductionc-akt proteincell typechromosomal sexcofactorcortical progenitorscortical stem cellcytotoxicdesigndesigningdimension reductiondimensionality reductionepistatic interactionepistatic relationshipextracellularfunctional outcomesgene manipulationgene modificationgene x gene interactiongenetic epistasesgenetic evolutiongenetic manipulationgenetic sexgenetically manipulategenetically modifiedgenetically perturbgenotypic sexhealthy aginghealthy human aginghiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsin silicoin vitro Modelin vivo Modelinduced human pluripotent stem cellsinnovateinnovationinnovativeinorganic phosphateinsightinsulinlike growth factornecrocytosisnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneurological diseaseneuron progenitorsneuron toxicityneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuronal toxicityneuroprogenitorneurotoxicitynutritiousp53 Antigenp53 Genesp53 Tumor Suppressorpathwaypharmacologicprogenitor and neural stem cellsprotein p53proto-oncogene protein RACproto-oncogene protein aktrac protein kinasereduce data dimensionreduce dimensionalityrelated to A and C-proteinresponsesexsmall moleculesocial roletransgenictranslation
Description preview
PROJECT SUMMARY
Our understanding of how chronic Mn may trigger or promote central nervous system (CNS) morbidities remains
fragmentary. Here, we seek to continue our studies into the mechanisms of Mn neurotoxicity by focusing on
chronic exposures. Acute Mn cellular neurotoxicity occurs by alterations in cell signaling pathways that normally
rely…
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