grant
Mechanisms of Lamin A/C-mediated Cardiac Conduction Disorders
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 25 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureA-V NodeATAC sequencingATAC-seqATACseqAV NodeAction PotentialsAffectAgeAge MonthsArrhythmiaAssay for Transposase-Accessible Chromatin using sequencingAtrialAtrio-Ventricular NodeAtrioventricular BlockAttenuatedBody TissuesBradyarrhythmiasBundle Branch disorderBundle-Branch BlockC proteinCardiacCardiac ArrhythmiaCardiac AtriumCardiac BlockCardiac ChronotropismCardiac conduction systemCardiomyopathiesCell BodyCell DifferentiationCell Differentiation processCellsCessation of lifeChromatin StructureCongestive CardiomyopathyCrossbreedingDNA mutationDeathDevelopmentDilated CardiomyopathyDimensionsDiseaseDisorderDysfunctionECGEKGEchocardiogramEchocardiographyElectrocardiogramElectrocardiographyElectrophysiologyElectrophysiology (science)FamilyFibrosisFoundationsFunctional disorderGene ExpressionGeneral PopulationGeneral PublicGenerationsGenetic ChangeGenetic HybridizationGenetic defectGenetic mutationGoalsHeartHeart ArrhythmiasHeart AtriumHeart BlockHeart Conduction SystemHeart RateHeart failureHeterozygoteHistologyImpairmentInjectionsIon ChannelIonic ChannelsKI miceKO miceKnock-in MouseKnock-out MiceKnockout MiceLamin ALamin Type ALaminsLeftLightLinkLoxP-flanked alleleMapsMediatingMembrane ChannelsMiceMice MammalsMicroscopyMolecularMurineMusMuscle Cell ContractionMuscle ContractionMuscle DiseaseMuscle DisordersMuscular ContractionMuscular DiseasesMutateMutationMyocardial DiseasesMyocardial DisorderMyocardiopathiesMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyNeurophysiology / ElectrophysiologyNodalNonsense MutationNull MouseOpticsPace StimulatorsPacemakersPathogenesisPathologicPathway interactionsPatientsPhenotypePhotoradiationPhysiopathologyPredispositionRNA SeqRNA sequencingRNAseqRefractoryRegulationReporterRoleSA node dysfunctionSick Sinus SyndromeSkeletal MuscleSurfaceSusceptibilitySystemTamoxifenTestingTherapeuticTimeTissuesTransthoracic EchocardiographyType V IF ProteinVentricularVentricular ArrhythmiaVoluntary MuscleWorkagesalternative treatmentassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingatrioventricular nodeatriumattenuateattenuatescalcium-activated potassium channel small-conductancecardiac failurecardiac pacemaker cellcardiac pacingcellular differentiationcitrate carriercitrate periplasmic carrier proteincitrate transportercitrate-binding transport proteindevelopmentalelectrophysiologicalepigenetic regulationfloxedfloxed allelegenome mutationheart sonographyheterozygosityhistologic studieshistological studiesimaging studyimplantationinduced Creinducible Creinsightkindredknockin micemouse modelmurine modelmuscular disordermyocardium diseasemyocardium disordernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynodal myocytenon-sense mutationnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachopticalpacemaker cellpatch clamppathophysiologypathwaypostnatalsinoatrial node dysfunctionsinus node dysfunctionsocial rolestandard carestandard treatmentthree dimensional structuretranscriptome sequencingtranscriptomic sequencingtricarboxylate carriertricarboxylate transportertricarboxylate-binding C protein
Description preview
PROJECT SUMMARY
The cardiac conduction system (CCS) is specialized in the generation and propagation of electrical impulses
from the atria to the ventricles to produce a highly coordinated muscle contraction. Cardiac conduction disorders
(CCDs) including sick sinus syndrome, atrioventricular block (AVB), and bundle branch block are common…
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