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Mechanisms of Iron-Sulfur Dependent Reactions

Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 Apr 2017Deadline 31 Jul 2025 ⚠️
NIHUS FederalResearch GrantFY2025AdemetionineAdoMetAnabolismAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsArchitectureBindingBiologicalBiologyCarbapenemsCarbohydratesCarbonCobalaminDNADeoxyribonucleic AcidEC 2.1.1EC 2.1.1.31-36Engineering / ArchitectureEnzyme GeneEnzymesFe elementFree RadicalsHealthHerbicidesHumanIronLipidsMethylationMethyltransferaseMiscellaneous AntibioticModern ManMolecular InteractionNatural ProductsNitrogenNon-Polyadenylated RNAO elementO2 elementOxygenPathway interactionsPhosphorousPhosphorusPrevalenceProcessProteinsRNARNA Gene ProductsRNA MethylasesRNA, Transfer, MethyltransferasesReactionResistanceResistance to antibioticsResistant to antibioticsRibonucleic AcidS elementS-AdenosylhomocysteineS-AdenosylmethionineS-adenosyl methionineS-adenosyl-methionineSAMeSourceSulfurSystemT RNA MethyltransferasesTherapeutic FungicidesThiostreptonWorkanti-canceranti-fungalanti-fungal agentsanti-fungal drugantibiotic drug resistanceantibiotic resistantbiologicbiosynthesiscarbanioncofactorenzyme structuremacromoleculemethyl groupmethylasenaturally occurring productpathwayresistantsmall moleculetRNA Methyltransferasestransmethylase

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Description preview

PROJECT SUMMARY/ABSTRACT
The prevalence and significance of methylation reactions in biology is well established. Methyl groups are
appended to a wide array of biological molecules, including numerous small-molecule metabolites and natural
products, and various macromolecules, such as proteins, DNA, RNA, carbohydrates, and lipids. In the vast…

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