grant
Mechanisms of immunopathology of COVID-19/ARDS, and strategies to mitigate detrimental inflammatory responses
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AGTR2AGTR2 geneAT2Active Follow-upAcuteAlveolarAnimalsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAnti-viral AgentsAvian InfluenzaB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BALB C MouseBALB/cBCDFBDNFBSF-2BSF2Bird FluBody TissuesBody Weight decreasedBrainBrain Nervous SystemBrain-Derived Neurotrophic FactorBypassCCL2CCL2 geneCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID associated ARDSCOVID associated acute respiratory distress syndromeCOVID crisisCOVID epidemicCOVID induced ARDSCOVID induced acute respiratory distress syndromeCOVID pandemicCOVID related ARDSCOVID related acute respiratory distress syndromeCOVID-19COVID-19 associated ARDSCOVID-19 associated acute respiratory distress syndromeCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 induced ARDSCOVID-19 induced acute respiratory distress syndromeCOVID-19 infectionCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 related ARDSCOVID-19 related acute respiratory distress syndromeCOVID-19 therapyCOVID-19 treatmentCOVID-19 virus infectionCOVID-19 yearsCOVID-19/ARDSCOVID-19/acute respiratory distress syndromeCOVID/ARDSCOVID/acute respiratory distress syndromeCOVID19 associated ARDSCOVID19 associated acute respiratory distress syndromeCOVID19 induced ARDSCOVID19 induced acute respiratory distress syndromeCOVID19 infectionCOVID19 related ARDSCOVID19 related acute respiratory distress syndromeCOVID19/ARDSCOVID19/acute respiratory distress syndromeCV-19Cause of DeathCell BodyCell Communication and SignalingCell SignalingCell-Mediated Lympholytic CellsCellsCessation of lifeChemokine, CC Motif, Ligand 2ClinicalColchicineCombined Modality TherapyComplementComplement ProteinsCoronavirus Infectious Disease 2019Cytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesDataDeathDifferences between sexesDiffers between sexesDiseaseDisorderDoseEarly treatmentEncephalonEpithelial Cell ProliferationEpithelial CellsEpitheliumEquilibriumFailureFowl PestFowl PlagueFrequenciesGender BiasGene ExpressionGenetic DiversityGenetic VariationGoalsGrippeH1N1H1N1 VirusH5N1H5N1 virusHPGFHepatocyte-Stimulating FactorHospital AdmissionHospitalizationHost Defense MechanismHouse miceHumanHybridoma Growth FactorIFNIFN-beta 2IFNB2IL-6IL6 ProteinImageImmuneImmune destructionImmune mediated destructionImmune mediated therapyImmune responseImmunesImmunityImmunologically Directed TherapyImmunotherapyImpairmentInbred BALB C MiceInfectionInfiltrationInflammationInflammatoryInflammatory ResponseInfluenzaInfluenza A H5N1Influenza A Virus, H1N1 SubtypeInfluenza A Virus, H5N1 SubtypeInjuryInnate Immune ResponseInnate ImmunityInosineInterferonsInterleukin-6InterventionIntracellular Communication and SignalingJournalsKeratinKinasesLaboratoriesLiteratureLungLung Alveolar EpitheliaLung ParenchymaLung Respiratory SystemLung TissueLung damageLung infectionsMCAFMCP-1MCP1MGI-2MagazineMaintenanceMediatingMethodsMiceMice MammalsModelingModern ManMolecularMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMorbidityMorbidity - disease rateMouse StrainsMultimodal TherapyMultimodal TreatmentMurineMusMus musculusMyeloid CellsMyeloid Differentiation-Inducing ProteinNasopharynxNative ImmunityNatural ImmunityNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic InfiltrateNon-Specific ImmunityNonspecific ImmunityOrganOseltamivirOutcomePaperPathologicPathologyPatientsPhasePhosphatesPhosphotransferase GenePhosphotransferasesPlasmacytoma Growth FactorProcessProductionProliferatingPublishingRNA SeqRNA sequencingRNAseqReceptor ProteinRecommendationRecovery of FunctionReportingResidualResidual stateResistanceRhinopharynxRiskRoleSARS-CoV-2 associated ARDSSARS-CoV-2 associated acute respiratory distress syndromeSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 induced ARDSSARS-CoV-2 induced acute respiratory distress syndromeSARS-CoV-2 infectionSARS-CoV-2 pandemicSARS-CoV-2 related ARDSSARS-CoV-2 related acute respiratory distress syndromeSARS-CoV-2 therapySARS-CoV-2 treatmentSARS-CoV-2/ARDSSARS-CoV-2/acute respiratory distress syndromeSARS-CoV2 infectionSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSCYA2STAT3STAT3 geneScienceSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 pandemicSex BiasSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine A2Staining methodStainsStructureStructure of parenchyma of lungT-Cell DepletionT-CellsT-LymphocyteT-cell depletion therapyT-lymphocyte depletion therapyT8 CellsT8 LymphocytesTamifluTestingThrombusTissuesTransmissionTransphosphorylasesTropomyosinUpdateVaccinationViralViral PneumoniaVirusVirus ReplicationWeight LossWeight ReductionWorkZileutonactive followupadaptive immune responsealveolar epitheliumanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsavian fluavian influenza H5N1avian influenza H5N1 virusavian strains of influenzabalancebalance functionbiological signal transductionbody weight lossclinical effectcombination therapycombined modality treatmentcombined treatmentcomplementationcoronavirus disease 2019coronavirus disease 2019 associated ARDScoronavirus disease 2019 associated acute respiratory distress syndromecoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 induced ARDScoronavirus disease 2019 induced acute respiratory distress syndromecoronavirus disease 2019 infectioncoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease 2019 related ARDScoronavirus disease 2019 related acute respiratory distress syndromecoronavirus disease 2019 therapycoronavirus disease 2019 treatmentcoronavirus disease 2019/ARDScoronavirus disease 2019/acute respiratory distress syndromecoronavirus disease associated ARDScoronavirus disease associated acute respiratory distress syndromecoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease induced ARDScoronavirus disease induced acute respiratory distress syndromecoronavirus disease pandemiccoronavirus disease related ARDScoronavirus disease related acute respiratory distress syndromecoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease/ARDScoronavirus disease/acute respiratory distress syndromecoronavirus infectious disease-19cytokinedisease phenotypedrug actiondrug detectiondrug testingearly therapyepithelium regenerationflu infectionflu virus infectionfollow upfollow-upfollowed upfollowupfunctional recoveryhost responsehuman diseaseimagingimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunopathologyimmunoresponseimprovedinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfected with severe acute respiratory syndrome coronavirus 2inflammation markerinflammatory markerinfluenza in birdsinfluenza infectioninfluenza virus infectioninjuriesinorganic phosphateinterferon beta 2killer T celllife-threatening COVIDlife-threatening COVID-19life-threatening SARS-CoV-2life-threatening coronavirus diseaselife-threatening coronavirus disease 2019life-threatening severe acute respiratory syndrome coronavirus 2lung functionlung injurylung lobelung repairlung tissue repairmortalitymouse modelmulti-modal therapymulti-modal treatmentmurine modelnasopharnygealnew approachesnovel approachesnovel strategiesnovel strategypneumocytepreservationpreventpreventingprogenitorpulmonarypulmonary damagepulmonary functionpulmonary infectionspulmonary injurypulmonary repairpulmonary tissue damagepulmonary tissue injuryreceptorregenerate epitheliumrepairrepairedresistantresponseserious COVIDserious COVID-19serious SARS-CoV-2serious coronavirus diseaseserious coronavirus disease 2019serious severe acute respiratory syndrome coronavirus 2severe COVIDsevere COVID-19severe COVID19severe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 associated ARDSsevere acute respiratory syndrome coronavirus 2 associated acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome coronavirus 2 induced ARDSsevere acute respiratory syndrome coronavirus 2 induced acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2 related ARDSsevere acute respiratory syndrome coronavirus 2 related acute respiratory distress syndromesevere acute respiratory syndrome coronavirus 2 therapysevere acute respiratory syndrome coronavirus 2 treatmentsevere acute respiratory syndrome coronavirus 2/ARDSsevere acute respiratory syndrome coronavirus 2/acute respiratory distress syndromesevere coronavirus diseasesevere coronavirus disease 19severe coronavirus disease 2019severe severe acute respiratory syndrome coronavirus 2sex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssuccesssurfactanttherapeutic agent developmenttherapeutic developmentthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtransmission processtreat COVID-19treat SARS-CoV-2treat coronavirus disease 2019treat severe acute respiratory syndrome coronavirus 2viral multiplicationviral replicationvirus multiplicationwt-loss
Description preview
The SARS-CoV-2 global pandemic and the possible risk of emerging human transmission of H5N1 influenza (bird flu) has emphasized the need for better understanding of the pathobiology of lethal viral pneumonias to enable the development of therapeutics to complement success in vaccination. To date, our attempts to develop and employ mouse models of…
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