grant
Mechanisms of Immune Activation and Disease Progression in Animal Models
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusATAC sequencingATAC-seqATACseqAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAcuteAddressAfricanAfrican Green MonkeyAlimentary CanalAnimal ModelAnimal Models and Related StudiesAnimalsAntigensArchitectureAsianAssay for Transposase-Accessible Chromatin using sequencingBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessCercopithecus aethiopsChlorocebus aethiopsChronicChronic DiseaseChronic IllnessChronic PhaseCirculationClinicalDataDigestive TractDiseaseDisease ProgressionDisorderDown-RegulationElementsEngineering / ArchitectureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionGI TractGastrointestinal TractGastrointestinal tract structureGene TranscriptionGenetic TranscriptionGrivet MonkeyHIVHigh PrevalenceHistoryHumanHuman Immunodeficiency VirusesImmune Cell ActivationImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune systemImmunityImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsIn VitroIndividualInfectionInflammationKnowledgeLAV-HTLV-IIILaboratoriesLamina PropriaLeadLymphadenopathy-Associated VirusLymphatic TissueLymphoid TissueMacacaMacaqueMaintenanceMeasuresModern ManModificationMonkeysNational Institutes of HealthNatureOutcomePathogenesisPb elementPeripheralPersonsPhasePhilosophyPopulationPrimate Immunodeficiency VirusesPrimate LentivirusesPrimatesPrimates MammalsProductivityPrognosisRNA ExpressionRecording of previous eventsReportingResearchResistanceRoleSAIDSSIVSimian AIDSSimian AIDSsSimian Acquired Immune Deficiency SyndromeSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusesStudy SectionSubcellular ProcessSupporting CellT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTechnologyTimeTissue SampleTissuesTranscriptionUnited States National Institutes of HealthVirusVirus ReplicationVirus-HIVWorkalimentary tractarmassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingcell typechronic disorderdesigndesigningdigestive canalepigeneticallyexperienceheavy metal Pbheavy metal leadhistorieshypoimmunityimmune activationimmune deficiencyimmune functionimmunodeficiencyimmunogenimprovedin vivointerestmembermicrobialmicrobial diseasemicrobial productsmicrobiomemodel of animalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynon-human primatenonhuman primatenovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachresistantsimian lymphoproliferative syndromesocial roleviral multiplicationviral replicationvirus multiplication
Description preview
AGM STUDIES:
A crucial element in understanding the pathogenesis of lentiviral infections is to compare and contrast parameters between progressive and non-progressive infections. Indeed, elucidating the mechanisms underlying AIDS resistance of SIV-infected natural hosts may provide critical information to better understand AIDS pathogenesis. To…
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