grant
Mechanisms of gene regulation in bacterial defense islands
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY20253-D structure3-dimensional structure3D structureATP-protein phosphotransferaseAddressAerobacterB subtilisB. subtilisBacillus subtilisBacteriaBacterial GenomeBacterial InfectionsBacteriophagesBiochemicalBioinformaticsCRISPRCRISPR/Cas systemCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell SignalingCellsClinicalClustered Regularly Interspaced Short Palindromic RepeatsComplementComplement ProteinsComplexCyclicityDNADNA Binding DomainDNA DamageDNA InjuryDNA-Binding Protein MotifsDeoxyribonucleic AcidDevelopmentE coliE. coliElementsEnterobacterEscherichia coliGene Action RegulationGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGenomeGenomicsISG15ISG15 geneImmuneImmune systemImmunesInfectionInterferon-Induced Protein IFI-15KIntracellular Communication and SignalingIslandKinase Family GeneKinasesKnowledgeMitomycin CMobile Genetic ElementsModelingModificationMolecularMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantNeighborhoodsOligoOligonucleotidesPathogenesisPathogenicityPathway interactionsPeriodicityPhagesPhosphotransferase GenePhosphotransferasesPlasmidsProtein KinaseProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationReporterResearchResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugRhythmicitySignal PathwaySignal TransductionSignal Transduction SystemsSignalingStressStructureSystemTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscriptional ControlTranscriptional RegulationTransphosphorylasesUbiquitilationUbiquitinationUbiquitinoylationVirusWorkanalyze gene expressionbacteria infectionbacteria pathogenbacterial diseasebacterial pathogenbacterial virusbiological adaptation to stressbiological signal transductioncomplementationdefense responsederepressiondevelopmentalenvironmental stressesenvironmental stressorgene expression analysisgene expression assaygene regulatory networkglycogen synthase a kinasehydroxyalkyl protein kinasein vivointerestmodel organismmulti-drug resistantmultidrug resistantnoveloligospathogenic bacteriapathwayphosphorylase b kinase kinasephysiological defense responsepressurepromoterpromotorreaction; crisisreconstitutereconstitutionresponsestress responsestress; reactionthree dimensional structuretranscriptional profilingtranscriptome sequencingtranscriptomic sequencingubiquinationubiquitin conjugation
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PROJECT SUMMARY
Mechanisms of gene regulation in bacterial defense islands
Advancements in bioinformatics and the availability of tens of thousands of bacterial genome sequences
have enabled the discovery of diverse pathways in bacteria that defend against environmental stress and
bacteriophage (phage) infection. Over 100 different antiphage…
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