grant
Mechanisms of epithelial cell state changes during kidney injury
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Feb 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY2026Acute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAddressAffectAutomobile DrivingAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBinding ProteinsBiologic PhenomenaBiological PhenomenaBody TissuesCell BodyCell DifferentiationCell Differentiation processCell SurvivalCell ViabilityCellsChromatinChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalComplexDNA-Binding ProteinsDataDevelopmentDiseaseDisorderDistalEnhancer ElementsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpitheliumExpression SignatureGene ExpressionGene Expression ProfileGene OrganizationGene StructureGene Structure/OrganizationGene TargetingGeneHomologGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic Enhancer ElementGoalsHNF4HNF4-AlphaHNF4AHNF4A geneHepatocyte Nuclear Factor 4-AlphaHepatocyte Nuclear Factor, 4HomeostasisHomologHomologous GeneHomologueImpairmentIn VitroInjuryInjury to KidneyIntermediary MetabolismIschemiaKidneyKidney Urinary SystemLigand Binding ProteinLigand Binding Protein GeneLinkMapsMeasuresMetabolic ProcessesMetabolismModelingModificationMolecularMolecular InteractionNatural regenerationNephronsOxidative StressOxidative Stress InductionPatientsPatternPhenotypePhysiological HomeostasisPhysiologyPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProtein BindingProtein FamilyProtein ModificationProteinsRecoveryRegenerationRegulatory ElementRenal CellRepressionRoleStressSyndromeTCF14TestingTissuesTranscription Factor 14, Hepatic Nuclear FactorTranscription Factor Proto-OncogeneTranscription factor genesUriniferous TubeWorkWritingacute kidney injurybound proteincell regenerationcellular differentiationcellular regenerationchromatin modificationchronic kidney diseaseclinical practicecostdevelopmentaldomain mappingdrivingenhancer sequenceepigeneticallyepithelium regenerationgene expression patterngene expression signaturegene regulatory networkgenes structuregenetic enhancer sequencegenome scalegenome-widegenomewidehigh definitionhigh-resolutionhistone modificationin vitro Modelin vivoinjuriesinjury recoveryinjury responseinsightischemia injuryischemic injurykidney cellkidney epithelial cellkidney injurynovelpreventpreventingrecovery after injuryrecovery following injuryrecovery post injuryrecruitregenerateregenerate epitheliumrenalrenal epitheliumrenal injuryrepairrepairedresilienceresilientresponse to injurysocial roletranscription factortranscriptional profiletranscriptional signature
Description preview
ABSTRACT
The long-term goal of this project is to identify molecular and genetic mechanisms that determine and maintain
kidney epithelial cell states in normal physiology and in response to injury. Acute kidney injury (AKI) is a
common and costly clinical syndrome and contributes to the development of chronic kidney disease (CKD).
Epithelial cells…
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