grant
Mechanisms of endothelial cell differentiation during vasculogenesis
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 4 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AngioblastArteriesArteriovenous AngiomaArteriovenous HemangiomaArteriovenous malformationBar CodesBasal Transcription FactorBasal transcription factor genesBloodBlood IslandBlood Reticuloendothelial SystemBlood VesselsBody TissuesCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCUT&RUNCardiacCell BodyCell DifferentiationCell Differentiation processCell LineCell LineageCell OntogenyCell ReprogrammingCellLineCellsCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseClustered Regularly Interspaced Short Palindromic RepeatsDataDevelopmentDiseaseDisorderEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic Cardiovascular SystemEmbryonic DevelopmentEndothelial CellsEndotheliumFamilyFutureGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGoalsHematopoieticHereditaryHistoryIndividualInheritedKnock-outKnockoutLeadLineage TracingLinkLymphaticMapsMeasurementMesodermMiceMice MammalsMolecularMultipotent Stem CellsMurineMusNatural regenerationNutrientO elementO2 elementOrganOrganogenesisOxygenPathway interactionsPb elementPhasePhenotypePhylogenetic AnalysisPhylogeneticsPhylogenyPositionPositioning AttributeProcessProgenitor CellsRacemose AngiomaRacemose HemangiomaRecording of previous eventsRegenerationRegenerative MedicineRegulationResolutionRestRoleSingle cell seqSingle-Nucleus SequencingSpecific qualifier valueSpecifiedStrains Cell LinesSystemSystems DevelopmentTestingTherapeuticTissuesTranscription Factor Proto-OncogeneTranscription RepressorTranscription factor genesTranscriptional RepressorTreesVascular SystemVascular regenerationVascular remodelingVenousWorkYolk Sacbarcodeblood vessel developmentblood vessel formationcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular differentiationcellular lineage mappingcellular lineage trackingcellular reprogrammingclustered regularly interspaced short palindromic repeats screencultured cell linedevelopmentalendothelial progenitorendothelial progenitor cellendothelial stem cellgenetic repressorheavy metal Pbheavy metal leadhemopoietichiPSChigh definitionhigh-resolutionhistorieshuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsin vivoinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinsightmultipotent progenitormultipotent progenitor cellnovelnutrient requirementpathwayprogenitorrecruitregeneraterepairrepairedresolutionsrestorationsNuc-SeqscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell next generation sequencingsingle cell sequencingsingle cell sequencing assay for transposase accessible chromatinsingle cell technologysingle cell transcriptomic profilingsingle nucleus RNA-sequencingsingle nucleus seqsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem cellstooltranscription factortranscription regulatory networktranscriptomicsvascularvasculogenesisvitelline sac
Description preview
PROJECT SUMMARY/ ABSTRACT
Blood vessels are the earliest organs formed during embryonic development, and the embryonic cardiovas-
cular system is required for nutrient exchange and organogenesis. As early as mouse embryonic day (E) 7.5 in
the extraembryonic yolk sac blood islands and embryos, mesodermal precursors undergo the first cell fate de-…
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