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Mechanisms of Claudin-5 Regulation during Neuroinflammation
Organization BOISE STATE UNIVERSITYLocation BOISE, UNITED STATESPosted 1 Aug 2025Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years oldAcetylationAddressAdultAdult HumanAdventitial CellAffectAgonistAmentiaAnimalsApoplexyAstrocytesAstrocytusAstrogliaAttenuatedAutomobile DrivingAutoregulationBBB disruptionBBB functionBasal Transcription FactorBasal transcription factor genesBeta Cadherin-Associated ProteinBeta Proprotein Interleukin 1Beta-1 CateninBleedingBlood - brain barrier anatomyBlood PreservationBlood brain barrier dysfunctionBlood-Brain BarrierBrain MetastasisBrain TraumaBrain Vascular AccidentCNS DiseasesCNS Nervous SystemCNS agentCNS disorderCUL-2Cell BodyCell Communication and SignalingCell Culture TechniquesCell SignalingCellsCentral Nervous SystemCentral Nervous System AgentsCentral Nervous System DiseasesCentral Nervous System DisordersCentral Nervous System DrugsCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicCo-cultureCocultivationCocultureCoculture TechniquesDataDeacetylationDementiaDemyelinationsDevelopmental DelayDevelopmental Delay DisordersDiseaseDisease ProgressionDisorderDisseminated SclerosisDown-RegulationDrug DeliveryDrug Delivery SystemsDrug TherapyDysfunctionEAEEncephalopathiesEndothelial CellsEndotheliumExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisExtravasationFKHRFOXO1FOXO1AFOXO1A geneFollow-Up StudiesFollowup StudiesForkhead Box O1AForkhead in RhabdomyosarcomaFoundationsFunctional disorderFutureGeneral Transcription Factor GeneGeneral Transcription FactorsGoalsHDAC6HDAC6 geneHemato-Encephalic BarrierHemiplegiaHemorrhageHistopathologyHomeostasisIL-1 betaIL-1 βIL-1-bIL-1βIL1-BetaIL1-βIL1B ProteinIL1F2IL1βImmuneImmunesIn vivo analysisIndividualInflammationInflammatoryInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin-Dependent Tyrosine Protein KinaseInterleukin 1betaInterleukin-1 betaInterleukin-1βInterventionIntracellular Communication and SignalingKIAA0901KO miceKinasesKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLeakageLesionLightMediatingMetastatic Neoplasm to the BrainMetastatic Tumor to the BrainMetastatic malignant neoplasm to brainMiceMice MammalsModelingMolecularMultiple SclerosisMurineMusMyelinNerve DegenerationNeuraxisNeuron DegenerationNull MouseNutrientOccluding JunctionsOutcomePRO2286PalsyParalysedPathogenesisPatientsPericapillary CellPericytesPerivascular CellPharmacological TreatmentPharmacotherapyPhosphotransferase GenePhosphotransferasesPhotoradiationPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlegiaPositionPositioning AttributePreinterleukin 1 BetaProcessPropertyProteinsRegulationRepressionResearchRoleRouget CellsSeizuresSignal TransductionSignal Transduction SystemsSignalingSpecific Child Development DisordersSpillageSpinal ColumnSpineStrokeSystemT-CellsT-LymphocyteTechniquesTestingTherapeuticTight JunctionsTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransgenic MiceTransgenic ModelTransgenic OrganismsTransphosphorylasesTraumatic Brain InjuryUnited StatesVertebral columnWorkZonula Occludensadulthoodastrocytic gliaattenuateattenuatesautoimmune encephalomyelitisbackbonebeta catbeta cateninbiological signal transductionblood lossblood-brain barrier disruptionblood-brain barrier functionbloodbrain barrierbloodbrain barrier disruptionbloodbrain barrier functionbrain attackbrain micrometastasiscell culturecell culturescentral nervous system demyelinating diseasecentral nervous system demyelinating disordercentrally acting drugcerebral vascular accidentcerebrovascular accidentcostdemyelinatedisease modeldisorder modeldrivingdrug interventiondrug treatmenthemiplegichistone deacetylase 6in vivoin vivo evaluationin vivo testinginhibitorinnovateinnovationinnovativeinsightinsular sclerosisknock-downknockdownloss of function mutationmouse modelmurine modelneural degenerationneural inflammationneurodegenerationneurodegenerativeneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetoverexpressoverexpressionparalysisparalyticpathophysiologypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreservationpromoterpromotorresilienceresilientskillssocial rolesolutestrokedstrokessubstantia albatherapeutic targetthymus derived lymphocytetooltranscription factortransgenictransgenic traittraumatic brain damagewhite matterβ-catenin
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PROJECT SUMMARY
The blood-brain barrier (BBB) is a vital defender of the central nervous system (CNS) that allows for nutrient
exchange while blocking the entry of toxic factors or immune cells. However, its disruption is common in CNS
disorders and can drive their disease progression. As such, our long-term goals are to identify the mechanisms…
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