grant
Mechanisms of CD4 T cell help to myeloid cells in tuberculosis
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025(TNF)-αAccelerationAcuteAdoptive TransferAnti-Bacterial AgentsAntigen PresentationAntigen-Presenting CellsAntigensBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCachectinCause of DeathCell BodyCell CommunicationCell CountCell FunctionCell InteractionCell NumberCell PhysiologyCell ProcessCell ProtectionCell-to-Cell InteractionCellsCellular FunctionCellular Immune FunctionCellular PhysiologyCellular ProcessCharacteristicsCytoprotectionDataDevelopmentExpression SignatureGM-CSFGene ExpressionGene Expression ProfileGene TranscriptionGeneralized GrowthGenetic TranscriptionGranulocyte-Macrophage Colony-Stimulating FactorGrowthHeterogeneityHistamine-Producing Cell-Stimulating FactorIFN-GammaIFN-gIFN-γIFNGIFNγImmune InterferonImmunologyImpairmentIndividualInfectionInfection ControlInferiorInflammationInflammatoryInflammatory ResponseInnate Immune ResponseInterferon GammaInterferon Type IIKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLinkLoxP-flanked alleleLungLung Respiratory SystemM tbM tuberculosisM tuberculosis antigenM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis antigenM. tuberculosis infectionM.tb antigenM.tb infectionM.tuberculosis infectionMTB infectionMTB vaccineMacrophage-Derived TNFMarrow NeutrophilMarrow monocyteMediatingMiceMice MammalsMolgramostinMonocyte-Derived TNFMtb antigenMurineMusMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis antigensMycobacterium tuberculosis infectionMyeloid Cell ActivationMyeloid CellsNeutrophilic GranulocyteNeutrophilic LeukocyteNull MousePathway interactionsPhagocytesPhagocytic CellPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPredispositionRNA ExpressionRNA SeqRNA sequencingRNAseqResolutionRoleShapesSignal PathwaySiteSortingSubcellular ProcessSusceptibilitySynapsesSynapticT cell receptor repertoire sequencingT cell receptor sequencingT-CellsT-LymphocyteT4 CellsT4 LymphocytesTB infectionTB vaccineTC-GM-CSFTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTechniquesTeff cellTestingTimeTissue GrowthTranscriptionTuberculosisTuberculosis VaccinesTumor Necrosis FactorTumor Necrosis Factor-alphaTumor-Cell Human GM Colony-Stimulating FactorVaccine for TBVaccine for TuberculosisVaccinesWild Type Mouseaccessory cellamebocyteanti-TB vaccineanti-bacterialantigen based testantigen testcell typecytoprotectivedevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldisseminated TBdisseminated tuberculosiseffector T cellfloxedfloxed allelegene expression patterngene expression signatureimmune functionimmunogenimmunological synapseimmunological synapse formationimprovedin vivoinfection due to Mycobacterium tuberculosisinnovateinnovationinnovativelFN-Gammamonocytemtbneutrophilnew approachesnovel approachesnovel strategiesnovel strategyontogenypathwaypreservationprogramsprotein expressionresolutionsresponsesocial rolesynapsethymus derived lymphocytetooltranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtuberculosis infectiontuberculous spondyloarthropathyvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine candidates against tuberculosisvaccine developmentwildtype mouse
Description preview
ABSTRACT
CD4 T cells govern host control of M. tuberculosis (Mtb) infection. The diverse phagocytic myeloid cells
that harbor intracellular Mtb in the lungs require CD4 T cell help to activate antibacterial effector mechanisms.
Protection against tuberculosis (TB) depends on this cellular interaction, but it remains incompletely defined.
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