grant
Mechanisms of antibiotic failure during osteomyelitis
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AcuteAddressAgglutininsAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAutomobile DrivingBacteriaBacterial InfectionsBindingBlood ClottingBlood Coagulation Factor IBlood Coagulation Factor IIBlood Coagulation Factor OneBlood Factor OneBlood SerumBlood coagulationBody TissuesBone InfectionCausalityCell BodyCellsCharacteristicsChildhoodChronicClinicalClottingCoagulaseCoagulationCoagulation Factor ICoagulation Factor IICoagulation Factor OneCoagulation ProcessCommunicable DiseasesCoupledDataDebridementDetectionDifferentiation Reversal FactorDiseaseDisorderEndowmentEtiologyExposure toFactor IFactor IIFactor OneFailureFibrinFibrinogenFreezingGeneralized GrowthGenesGenus staphylococcusGoalsGrowthHistologicHistologicallyHost FactorHost Factor ProteinHumanImmuneImmune responseImmunesIn SituIn VitroInfectionInfectious DiseasesInfectious DisorderIntegration Host FactorsInterventionInvadedKnowledgeLabelLinkLipidsMeasuresMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMiceMice MammalsMicroscopyMiscellaneous AntibioticModalityModelingModern ManMolecular InteractionMorbidityMorbidity - disease rateMurineMusOperative ProceduresOperative Surgical ProceduresOsteomyelitisPathogenesisPathogenicity FactorsPatientsPatternPhenotypePhysiologicPhysiologicalPopulationPositionPositioning AttributePredispositionProceduresProcessProteinsProthrombinProtocolProtocols documentationReagentReporterResearch SpecimenRoleS aureusS. aureusS. aureus infectionSamplingSerumSpecimenStaph aureusStaph aureus infectionStaphylococcusStaphylococcus aureusStaphylococcus aureus infectionSurface ProteinsSurgicalSurgical InterventionsSurgical ProcedureSusceptibilityTestingTissue GrowthTissuesTn-seqTnseqTreatment EfficacyTreatment FailureTreatment PeriodVirulenceVirulence Factorsantibiotic tolerancebacteria infectionbacteria pathogenbacterial communitybacterial diseasebacterial disease treatmentbacterial geneticsbacterial infectious disease treatmentbacterial pathogenbonecausationcohortcombatdisease causationdrivingexperienceexperimentexperimental researchexperimental studyexperimentsgenetic approachgenetic strategygenome scalegenome-widegenomewidehost responseimaging mass spectrometryimmune system responseimmunoresponseimprovedimproved outcomein vitro activityin vivoinfected with S. aureusinfected with Staph aureusinfected with Staphylococcus aureusinnovateinnovationinnovativeintervention efficacymass spectrometric imagingmicrobialmolecular imagingmolecule imagingmouse modelmurine modelmutantnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathogenpathogenic bacteriapediatricpharmacologicsmall moleculesocial rolesurgerytherapeutic efficacytherapy efficacytherapy failuretolerance to antibioticstolerate antibioticstransposon insertion sequencingtransposon sequencingtreatment daystreatment duration
Description preview
PROJECT SUMMARY / ABSTRACT
Osteomyelitis is an invasive infection of bone most commonly caused by the bacterial pathogen
Staphylococcus aureus. Successful treatment of osteomyelitis requires prolonged antibiotic treatment as well as
invasive surgical procedures to remove infected and nonviable bone. Despite these aggressive measures, nearly
1 in…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click