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Mechanisms for recruitment and function of metazoan replication initiation factors

Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AddressAssayBaker's YeastBasal Cell Nevus SyndromeBindingBinding ProteinsBioassayBiochemicalBiological AssayBrewer's YeastBudding YeastCancersCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCell SurvivalCell ViabilityCellsCellular ExpansionCellular GrowthCellular ProliferationChromatinChromosomal AmplificationChromosomal DuplicationComplexCryo-electron MicroscopyCryoelectron MicroscopyDNADNA BindingDNA Binding InteractionDNA HelicasesDNA ReplicationDNA Replication InitiationDNA SequenceDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA boundDNA mutationDNA unwinding enzymeDataDedicationsDeoxyribonucleic AcidDepositDepositionDevelopmentDiseaseDisorderDwarfismElectron CryomicroscopyEndomycetalesEnvironmentEukaryotaEukaryoteEventFailureFifth PhacomatosisGeneralized GrowthGenetic ChangeGenetic defectGenetic mutationGenome InstabilityGenomic InstabilityGenomicsGoalsGorlin SyndromeGorlin syndrome 2Gorlin-Goltz SyndromeGrowthIn VitroInitiation FactorsKnowledgeLabelLaboratoriesLearningLicensingLifeLigand Binding ProteinLigand Binding Protein GeneLinkMaintenanceMalignant NeoplasmsMalignant TumorMediatingModelingMolecularMolecular InteractionMotorMutationNanismNevoid Basal Cell Carcinoma SyndromeNucleosomesORC proteinOrganismOutcomePeptide Initiation FactorsPositionPositioning AttributeProcessProtein BindingProteinsRegulationReplication InitiationReplication OriginResearchResearch ProposalsS cerevisiaeS. cerevisiaeSaccharomyces cerevisiaeSaccharomycetalesSiteSpecific qualifier valueSpecifiedStructureSystemTechniquesTestingTissue GrowthTranslation Initiation FactorTranslational Initiation FactorWorkYeast Model Systembiochemical modelbound proteincell growthcofactorcryo-EMcryoEMcryogenic electron microscopydevelopmentaldwarfgenetic informationgenome mutationhelicasehereditary cutaneomandibular polyoncosishuman diseasein vivojaw cysts-basal cell tumors-skeletal anomalies syndromeliving systemmalignancymultiple basal-cell carcinoma syndrome multiple basal-cell nevus syndromemultiple hereditary cutaneomandibular polyoncosismultiple nevoid basal-cell carcinoma syndromemultiple nevoid basal-cell epithelioma-jaw cysts-bifid rib syndromeneoplasm/cancernevoid basal-cell epithelioma-jaw cysts-bifid rib syndromenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachodontogenic keratocytosis-skeletal anomalies syndromeontogenyori Regionorigin recognition complexrecruityeast model

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Project Summary
The survival of living organisms depends on the timely and accurate duplication of chromosomal DNA. In all
domains of life, the onset of DNA replication (or initiation) relies on dedicated initiator proteins that bind
genomic sites, termed replication origins, and help load replicative helicases onto DNA. In eukaryotes, the…

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Mechanisms for recruitment and function of metazoan replication initiation factors — YALE UNIVERSITY | UNITED STATES | A | Dev Procure