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Mechanisms and relevance of miRNA decay during hematopoietic development

Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Aug 2024Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY2025ApoptosisApoptosis PathwayAssayBioassayBiogenesisBiological AssayBiologyBloodBlood CellsBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood Precursor CellBlood Reticuloendothelial SystemBody TissuesCell BodyCell Growth in NumberCell LineCell MultiplicationCell ProliferationCellLineCellsCellular ProliferationComplementComplement ProteinsComplexCristobaliteDNADNA mutationDataDegradation PathwayDegradative PathwayDeoxyribonucleic AcidDevelopmentEnsureExonucleaseFailureFunctional RNAFutureGene ExpressionGeneticGenetic ChangeGenetic defectGenetic mutationGoalsHematologic Body SystemHematologic Organ SystemHematopoiesisHematopoieticHematopoietic Body SystemHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic SystemHematopoietic stem cellsHumanImpairmentIn VitroInterventionKnowledgeMarrow NeutrophilMediatingMicroRNAsModelingModern ManMolecularMutationMyeloid ProgenitorMyeloid Progenitor CellsMyeloid Stem CellsNeutropeniaNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Polyadenylated RNANoncoding RNANontranslated RNAOrigin of LifePathogenicityPathway interactionsPatientsPeripheral Blood CellPhenotypePhysiologicPhysiologicalPlayPoly(A) TailPolyadenylationPolymerasePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPositionPositioning AttributePost-Transcriptional ControlPost-Transcriptional RegulationProcessProgenitor CellsProgrammed Cell DeathProtocolProtocols documentationRNARNA DecayRNA DegradationRNA Gene ProductsRNA PolyadenylationRNA ProcessingRibonucleic AcidRoleRouteSandSilicaSilicon DioxideSpecificityStrains Cell LinesSyndromeTailTestingTissuesTranscriptional ControlTranscriptional RegulationTridymiteUbiquitin Ligase Component GeneUbiquitin Ligase GeneUntranslated RNAadenylateblood cell formationblood cell progenitorblood formationblood progenitorblood stem cellblood-forming stem cellbone marrow failure syndromecell typecomplementationcultured cell linedevelopmentalexosomegenome mutationgenome scalegenome-widegenomewideglobal gene expressionglobal transcription profilehESChematopoietic differentiationhematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellhuman ES cellhuman ESChuman derived pluripotent stem cellhuman embryonic stem cellhuman pluripotent stem cellhuman tissuein vivomiRNAmutantmyeloid precursormyeloid stem and progenitor cellneutrophilnoncodingnovelpathwaypost-transcriptional gene regulationprogenitorsocial rolestemstem cellstooltranscriptomeubiquitin ligase

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PROJECT SUMMARY/ABSTRACT
MicroRNAs (miRNAs) are essential regulators of the human transcriptome and play a central role in
tissue development. As the hematopoietic system is composed of a multitude of mature cell types constantly
produced from stem and progenitor cells, it is not surprising that correct miRNA biogenesis, function, and decay
are…

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Mechanisms and relevance of miRNA decay during hematopoietic development — WASHINGTON UNIVERSITY | UNITED STATES | Aug 2 | Dev Procure