grant
Mechanisms and Neuroprotective Targets in Alcohol-Induced Brain Injury
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 11 May 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAcquired brain injuryAcuteAddressAffectAlcohol Chemical ClassAlcohol-Induced DisordersAlcoholsAnimalsApoptosisApoptosis PathwayAssayAutomobile DrivingBBB permeabilizationBBB permeableBasal Transcription FactorBasal transcription factor genesBehaviorBehavioralBehavioral AssayBioassayBioinformaticsBiological AssayBirthBody TissuesBrainBrain InjuriesBrain Nervous SystemBrain regionCalciumCalcium Ion SignalingCalcium SignalingCell BodyCell Communication and SignalingCell SignalingCellsChromosome MappingCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDNA Molecular BiologyDataDephosphinDevelopmentDisturbance in cognitionDynaminEarly InterventionEarly treatmentEconomic BurdenEncephalonExhibitsExpression SignatureFASDFetal Alcohol Spectrum DisorderFunctional impairmentGene ExpressionGene Expression ProfileGene LocalizationGene MappingGene Mapping GeneticsGene ModifiedGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGoalsHealthHistologyHumanImageImpaired cognitionImpairmentInduced pluripotent stem cell derived human neuronInner mitochondrial membraneIntellectual disabilityIntellectual functioning disabilityIntellectual limitationInterventionIntracellular Communication and SignalingKnowledgeLinkage MappingMapsMediatingMitochondriaMitochondrial ProteinsModelingModern ManMolecularMolecular BiologyMolecular Biology TechniquesNerve CellsNerve UnitNeural CellNeuritesNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsParturitionPathologicPathologyPatientsPeptide DomainPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrecision therapeuticsPredispositionPrevalenceProcessProgrammed Cell DeathProtein DomainsProtein ModificationProteinsPublic HealthRegulationResearchSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStressSusceptibilityTechniquesTechnologyTertiary Protein StructureTestingTissuesTotal Human and Non-Human Gene MappingToxic effectToxicitiesTranscription Factor Proto-OncogeneTranscription factor genesUnited StatesVirusalcohol effectalcohol exposedalcohol exposurealcohol induced injuryalcohol-induced damageassess effectivenessbehavior testbehavioral impairmentbehavioral testbiological signal transductionblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrier permeabilizationbloodbrain barrier permeablebrain cellbrain damagebrain tissuebrain-injuredcalcium uniportercell typeclinical applicabilityclinical applicationcognitive dysfunctioncognitive functioncognitive losscostdetermine effectivenessdevelopmentaldevelopmental neurotoxicitydrivingearly therapyeconomic costeffectiveness assessmenteffectiveness evaluationethanol effectethanol exposedethanol exposureethanol induced injuryethanol-induced disorderevaluate effectivenessexamine effectivenessexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolfetalgene expression patterngene expression signaturegene manipulationgene modificationgenetic manipulationgenetic mappinggenetically manipulategenetically modifiedgenetically perturbhiPSChiPSC-derived neuronshuman iPShuman iPSChuman iPSC-derived sensory neuronhuman induced pluripotent cellhuman induced pluripotent stem cell derived sensory neuronhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman progenitorhuman stem cellsiPSiPSCiPSC-derived human neuroniPSCsimagingimaging systemimpaired behaviorinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinducible pluripotent stem cell derived human neuroninducible pluripotent stem cell derived human sensory neuroninnovateinnovationinnovativeinsightintellectual and developmental disabilityinterdisciplinary approachlimited intellectual functioningmitochondrialmitochondrial dysfunctionmouse modelmulti-photon imagingmultidisciplinary approachmultiphoton excitation microscopymultiphoton imagingmultiphoton microscopymurine modelnerve cell deathnerve cell lossneurodevelopmental diseaseneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuronal survivalneurons differentiated from human induced pluripotent stem cellsneuroprotectionneuroprotectivenoveloverexpressoverexpressionpersonalized health interventionpersonalized interventionpharmacologicprecision interventionsprecision therapiesprecision treatmentpreventpreventingprogenitor cell modelprogenitor modelsensorsmall moleculesocietal costsspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelthree dimensionaltranscription factortranscriptional profiletranscriptional signaturetranslational opportunitiestranslational potential
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PROJECT SUMMARY
Fetal Alcohol Spectrum Disorders (FASD) represent a major public health concern, significantly contributing to
intellectual disabilities with a prevalence rate of 1-5% in the United States and an estimated annual economic
burden of $5 billion. Despite its substantial impact, there is currently no cure for FASD. Existing research,…
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