grant
Mechanisms and manipulation of force dependent behavior in T cell biology
Organization UNIVERSITY OF NOTRE DAMELocation NOTRE DAME, UNITED STATESPosted 2 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AccountingAddressAffectAffinityAntigenic DeterminantsAntigensAutomobile DrivingBehaviorBindingBinding DeterminantsBiological FunctionBiological ProcessBiologyCartoonsCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell Mediated ImmunologyCell PhysiologyCell ProcessCell SignalingCell-Mediated ImmunityCell-to-Cell InteractionCellular FunctionCellular ImmunityCellular PhysiologyCellular ProcessCellular biologyCollaborationsComplexComputer SimulationComputer based SimulationDNA mutationDiseaseDisorderEducationEducational aspectsEngineeringEpitopesGenetic ChangeGenetic defectGenetic mutationGoalsHealthImmuneImmune mediated therapyImmune systemImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunologistImmunotherapyInfectionIntracellular Communication and SignalingKineticsKnowledgeLCM VirusesLCMVLibrariesLigandsLymphocytic choriomeningitis virusMeasurementMembraneMiceMice MammalsMolecular InteractionMurineMusMutationNatureOutputPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPhysicsProductivityPropertyProteinsPublishingReceptor ProteinReceptors, Antigen, T-Cell, alpha-betaScienceSignal TransductionSignal Transduction SystemsSignalingSpecificityStructureSubcellular ProcessT Cell SpecificityT cell responseT-Cell Immunologic SpecificityT-CellsT-LymphocyteTcR alpha-betaTcR αβTestingThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTumor AntigensTumor-Associated AntigenVariantVariationViralViral AntigensViral DiseasesVirus DiseasesWorkWritingalpha-beta T-Cell Receptorbiological signal transductioncancer antigenscell behaviorcell biologycellular behaviorcomputational frameworkcomputational simulationcomputer based predictioncomputer frameworkcomputerized simulationdesigndesigningdrivingfootfrontiergenome mutationimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunogenicityimprovedinfancyinfantileinterestlenslensesmechanical forcemembrane structurepMHCpredictive modelingreceptorresponsescreeningscreeningssimulationsuccesstheoriesthymus derived lymphocytetumor-specific antigenviral infectionvirus antigenvirus infectionvirus-induced diseaseαβ T-Cell Receptor
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Summary
TCR recognition of peptides bound and presented by MHC proteins underlies cellular immunity. TCR recognition
of pMHC is most often viewed through the lens of traditional receptor-ligand theory, where cellular responses
are presumed to be governed by solution binding affinities or kinetics. While this is often the case, work over the
past…
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