🗂️
Archived grant — no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Mechanisms and Impact of Islet Vascular Inflammation in Diabetes
Organization VA PUGET SOUND HEALTHCARE SYSTEMLocation SEATTLE, UNITED STATESPosted 1 Jan 2019Deadline 31 Mar 2026 ⚠️
VANIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAdult-Onset Diabetes MellitusAdventitial CellAffectAmputationAmyloidAmyloid SubstanceAnimal ModelAnimal Models and Related StudiesAutoregulationB9 endocrine pancreasBeta CellBlindnessBlood VesselsBlood capillariesBlood flowBody TissuesBrainBrain Nervous SystemC-Type LectinsCell BodyCell Communication and SignalingCell DeathCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell modelCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelCrossbreedingDataDefectDepositDepositionDevelopmentDiabetes MellitusDiabetic Kidney DiseaseDiabetic NephropathyDiabetic RetinopathyDysfunctionECMESKDESRDEncephalonEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEndocrine PancreasEndothelial CellsEndotheliumExtracellular MatrixExtravasationFailureFamilyFunctional disorderGenetic HybridizationHealthHealth Care SystemsHomeostasisHumanHumulin RHyperglycemiaImpairmentIn VitroInflammationInsulinInsulin CellInsulin Secreting CellInsulinoma amyloid peptideIntracellular Communication and SignalingIslands of LangerhansIslet CellIslets of LangerhansKetosis-Resistant Diabetes MellitusKnowledgeLeakageLytotoxicityMaturity-Onset Diabetes MellitusMediatingMediatorMiceMice MammalsMicrovascular DysfunctionModelingModern ManMolecularMurineMusNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNutrientPancreasPancreaticPancreatic IsletsParacrine CommunicationParacrine SignalingPars endocrina pancreatisPathogenesisPathologyPathway interactionsPatientsPericapillary CellPericytesPeripheralPerivascular CellPhysiological HomeostasisPhysiopathologyPlayPopulationPredispositionRNA SeqRNA sequencingRNAseqRegular InsulinRoleRouget CellsSignal TransductionSignal Transduction SystemsSignalingSliceSlow-Onset Diabetes MellitusSourceSpillageStable Diabetes MellitusSubcellular ProcessSusceptibilityT2 DMT2DT2DMTissuesToxic effectToxicitiesTransgenic MiceType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVascular DiseasesVascular DisorderVascularizationVeteransWorkadult onset diabetesamlintideamylinbeta cell developmentbiological signal transductionblood vessel disordercapillarycell typecytotoxicitydevelopmentaldiabetesdiabetes associated peptideendocrine pancreas developmenthuman datahyperglycemicin vivoinsulinoma amyloid polypeptideisletislet amyloid polypeptideislet developmentketosis resistant diabeteskidney fibrosismaturity onset diabetesmembermicrovascular complicationsmicrovascular diseasemodel of animalnecrocytosisneural inflammationneuroinflammationneuroinflammatorynovelpancreatic amylinpathophysiologypathwaypreventpreventingrenal fibrosisresponsesmall vessel diseasesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthree dimensionaltranscriptome sequencingtranscriptomic sequencingtype 2 DMtype II DMtype two diabetesvascularvascular abnormalityvascular dysfunctionvascular inflammationvasculopathyvision lossvisual lossβ-cellβ-cellsβCell
Applications closed.
Description preview
Insufficient release of insulin from the pancreatic islet β cell is a critical defect in type 2 diabetes (T2D).
Pancreatic islets are highly vascularized, and this vasculature is essential for nutrient supply to islet cells,
insulin delivery to peripheral tissues and as a rich source of signals that support β-cell function. In human T2D
and animal…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click