grant
Mechanisms and consequences of erythritol and erythronate excess in cardiometabolic disease
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 1 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years oldASCVDAdultAdult HumanAdult-Onset Diabetes MellitusAdvisory CommitteesApproaches to preventionArtificial SweetenersAtherosclerosisAtherosclerosis Risk in CommunitiesAtherosclerotic Cardiovascular DiseaseBMIBMI percentileBMI z-scoreBiologicalBiological MarkersBiometricsBiometryBiostatisticsBlood PlasmaBlood SerumBoard CertificationBody mass indexCardiac DiseasesCardiac DisordersCardiometabolic DiseaseCardiometabolic DisorderCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCausalityCessation of lifeClinical ResearchClinical StudyCoronary DiseaseCoronary heart diseaseD-GlucoseDataDeathDextroseDiabetes MellitusDiagnosisDietary intakeEducational AchievementEducational StatusEndocrinologistEnvironmentEnzyme GeneEnzymesEpidemicEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationEtiologyEventFastingFood productionFundingGWA studyGWASGene variantGenesGeneticGenetic DiversityGenetic VariationGenomic approachGluconeogenesisGlucoseGlycolaldehydetransferaseGlycolysisGoalsHCHS/SOL StudyHCHS/SOL cohortHeart DiseasesHeart VascularHeart failureHexose Monophosphate ShuntHispanic Community Health Study/Study of LatinosHospital AdmissionHospitalizationHyperglycemiaIncidenceInfusionInfusion proceduresIngestionIntakeIntermediary MetabolismKetosis-Resistant Diabetes MellitusLinkMaturity-Onset Diabetes MellitusMedicineMendelian randomizationMentorsMeta-AnalysisMetabolic PathwayMetabolic ProcessesMetabolismMicrovascular DysfunctionNIDDMNational Institutes of HealthNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityObservation researchObservation studyObservational StudyObservational researchOralOutcomePathway interactionsPentose Phosphate PathwayPentose Phosphate ShuntPentose ShuntPentosephosphate PathwayPentosephosphate ShuntPersonalized medical approachPersonsPhosphatesPhysiciansPlasmaPlasma SerumPopulation HeterogeneityPrevalencePrevention approachPrimary PreventionProductionProteomicsQuetelet indexResearchResearch ProposalsResearch TrainingReticuloendothelial System, Serum, PlasmaRiskRisk AssessmentRisk FactorsRoleSafetySamplingSampling StudiesScientistSerumSlow-Onset Diabetes MellitusStable Diabetes MellitusT2 DMT2DT2DMTask ForcesTestingTracerTrainingTransketolaseType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited States National Institutes of HealthVascular DiseasesVascular DisorderVisitadiposityadult onset diabetesadulthoodadvisory teamallelic variantatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebio-markersbiologicbiologic markerbiomarkerblood vessel disordercardiac failurecardiometabolic riskcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcareer developmentcausationcirculatory systemclinical investigationclinical predictorscollegecollegiatecoronary disordercorpulencediabetesdietarydisease causationdiverse populationseducational levelenhancing factorenzyme pathwayethnic subgroupethnicity groupfastedfastsgenetic variantgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic effortgenomic strategygenomic variantglucose biosynthesisheart disorderheterogeneous populationhyperglycemicindividualized approachinfusionsingestinorganic phosphateketosis resistant diabetesmacrovascular complicationmacrovascular diseasematurity onset diabetesmetabolism measurementmetabolomicsmetabonomicsmicrovascular complicationsmicrovascular diseasemortalitymulti-ethnicmultiethnicmultiomicsmultiple omicspandemicpandemic diseasepanomicspathwaypersonalized approachpopulation diversityprecision approachprofessorresponseskillssmall vessel diseasesocial rolestable isotopetailored approachtenure processtenure tracktraining achievementtraining leveltraining statustype 2 DMtype II DMtype two diabetesvascular dysfunctionvasculopathywhole genome association analysiswhole genome association study
Description preview
PROJECT SUMMARY/ABSTRACT
The obesity and type 2 diabetes (T2D) epidemics parallel a rise in atherosclerotic cardiovascular disease
(ASCVD), and heart failure (HF). Elevated serum erythritol concentrations have been linked to increased
ASCVD with erythritol ingestion as an artificial sweetener implicated. Erythritol has been shown to be…
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