grant
Mechanism of Motor Learning Impacting Cognitive and Emotional State
Organization GEORGE WASHINGTON UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 1 Mar 2026Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY20260-11 years old2 year old2 years of age2-photonAffectAffectiveAttenuatedBehaviorBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral AssayBehavioral Conditioning TherapyBehavioral ModificationBehavioral ParadigmBehavioral TherapyBehavioral TreatmentBirthBrainBrain Nervous SystemCNS plasticityCalciumCell Communication and SignalingCell SignalingCerebroatrophic HyperammonemiaChildChild YouthChildren (0-21)CognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalConditioning TherapyDNA mutationDataData AnalysesData AnalysisDevelopmentDiseaseDisorderDisturbance in cognitionEmotionalEncephalonEquilibriumExerciseFellowshipFemaleGenesGeneticGenetic ChangeGenetic defectGenetic mutationHeadImageImaging ProceduresImaging TechnicsImaging TechniquesImpaired cognitionImpairmentIn vivo two-photon calcium imagingIncrease lifespanIntracellular Communication and SignalingInvestigationInvestigatorsKO miceKnock-out MiceKnockout MiceKnowledgeLeadLearningLearning SkillLinkMeCP-2 proteinMeCP2MeCP2 proteinMedialMemoryMethyl CpG binding protein MeCP2Methyl-CpG-Binding Protein 2Methyl-DNA binding protein MECP2MiceMice MammalsModelingMolecularMonitorMotorMotor CortexMotor SkillsMurineMusMutationNatural HistoryNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurodevelopmental DisorderNeurologic DisordersNeurological Development DisorderNeurological DisordersNeuronal PlasticityNeuronsNull MousePaperParturitionPb elementPrefrontal CortexProcessPyramidal neuronResearchResearch PersonnelResearchersRett DisorderRett SyndromeRodent ModelRunningScienceSensorySignal TransductionSignal Transduction SystemsSignalingSocial BehaviorSocial FunctioningSpeechSpeedSubgroupSymptomsSynapsesSynapticTechniquesTestingTherapeutic InterventionTimeTrainingTraining ProgramsViral VectorWild Type MouseWorkX Chromosomeage 2age 2 yearsaged 2 yearsaged two yearsanxiety reductionanxiety-like behaviorattenuateattenuatesbalancebalance functionbehavior interventionbehavior testbehavioral interventionbehavioral testbiological signal transductionboost longevitycareer developmentcentral nervous system plasticitycognitive defectscognitive dysfunctioncognitive functioncognitive losscognitive skillcomputerizeddata interpretationdevelopmentalelongating the lifespanemotion regulationemotional regulationenhance longevityexcitatory neuronextend life spanextend lifespanextend longevityfoster longevityfunction sociallyfunctioning socialgenome mutationheavy metal Pbheavy metal leadhippocampal pyramidal neuronimagingimaging in vivoimprove lifespanimprove longevityimprovedin vivoin vivo calcium imagingin vivo imaginginnovateinnovationinnovativeinterpersonal competenceinterpersonal competencyintervention therapyjuvenile animalkidslifespan extensionlocomotor learningmalemicroscope imagingmicroscopic imagingmicroscopy imagingminiaturizeminiaturizedmotor abilitymotor diseasemotor disordermotor dysfunctionmotor learningmotor skill learningneural circuitneural circuitryneural imagingneural plasticityneuro-imagingneurocircuitryneurodevelopmental diseaseneuroimagingneurological diseaseneurological imagingneuronalneuroplasticneuroplasticityoptogeneticsperceptual motor learningphysical impairmentprolong lifespanprolong longevitypromote lifespanpromote longevityskillssocialsocial competencesocial competencysocial skillssociobehaviorsociobehavioralsupport longevitysynapsesynaptic circuitsynaptic circuitrytherapeutically effectivetreadmilltwo year oldtwo years of agetwo-photonwildtype mouseyoung animalyoungster♀♂
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PROJECT SUMMARY
Rett syndrome is a severe neurodevelopmental disorder caused by mutations on the MECP2 gene located on
the X chromosome, predominantly affecting females. Resulting symptoms include impairments in speech,
motor coordination, learning and memory, cognition, and social functioning. Importantly, motor learning
paradigms have shown…
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