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Mechanism of Immune Dysfunction and Morbid Outcomes in Response to Shock/Sepsis
Organization RHODE ISLAND HOSPITALLocation PROVIDENCE, UNITED STATESPosted 1 May 2016Deadline 30 Apr 2025 ⚠️
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAccountingAcute Lung InjuryAcute Pulmonary InjuryAdoptive TransferAgeAnimalsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoptosisApoptosis PathwayAreaAssay for Transposase-Accessible Chromatin using sequencingAutomobile DrivingBlood leukocyteCLP modelCLP mouse modelCOVID-19 infectionCOVID-19 virus infectionCOVID19 infectionCausalityCause of DeathCecal ligation perforationCell BodyCell surfaceCellsCellular Immune FunctionCessation of lifeCirculatory CollapseClinical ResearchClinical StudyConsensusCre-LoxCre-LoxPCre/LoxPCritical IllnessCritically IllDeathDefectDeveloped CountriesDevelopmentEndotheliumEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEtiologyEventFamilyFrustrationGeneticHemorrhagic ShockHospitalsImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune memoryImmune systemImmunesImmunologic DiseasesImmunologic MemoryImmunological DiseasesImmunological DysfunctionImmunological MemoryImmunological System DysfunctionIncidenceIndustrialized CountriesIndustrialized NationsInjuryIntensive Care UnitsIntestinalIntestinesLeukocytesLeukocytes Reticuloendothelial SystemLigandsLiverLymphatic cellLymphocyteLymphocyticLymphoid CellMOF syndromeMarrow leukocyteModelingMolecularMorbidityMorbidity - disease rateMultiple Organ Dysfunction SyndromeMultiple Organ FailureMyelogenousMyeloidOutcomePatientsPopulationPredispositionPrognostic MarkerProgrammed Cell DeathProtein FamilyProteinsRNA SeqRNA sequencingRNAseqReceptor ProteinReportingRoleSARS-CoV-2 infectionSARS-CoV2 infectionSepsisSevere acute respiratory syndrome coronavirus 2 infectionShockSupportive TherapySupportive careSuppressor CellsSuppressor-Effector T-CellsSuppressor-Effector T-LymphocytesSurgical Intensive CareSurvivorsSusceptibilityT Suppressor CellT-Cell ActivationWhite Blood CellsWhite Cellactivate T cellsagesanamnestic reactionassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbisulfitebowelcausationcecal ligation and perforationcecal ligation and puncturececal ligation puncturececum ligation and puncturececum ligation puncturecirculatory shockcomparativecoronavirus disease 2019 infectiondesigndesigningdeveloped countrydeveloped nationdeveloped nationsdevelopmentaldisease causationdrivingepigeneticallyepigenomicshepatic body systemhepatic organ systemhydrogen sulfitehydrosulfiteimmune functioninfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2inhibitorinjuredinjuriesinjury to organskidney dysfunctionlymph cellmembermicrobial consortiamicrobial floramicrobiotamicrofloramortalitymouse modelmultiorgan failuremultiple organ system failuremultispecies consortiamurine modelneonatal sepsisneonatenovelorgan developmentorgan growthorgan injurypatient populationprognostic biomarkerprognostic indicatorprogramsprotein expressionpulmonarypyrosequencingreceptorrenal dysfunctionresponsescRNA sequencingscRNA-seqsecondary immune responsesepticshockssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesuppressor T lymphocytetherapeutic targettranscriptome sequencingtranscriptomic sequencingtranscriptomicswhite blood cellwhite blood corpuscle
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Description preview
A. Summary/Abstract:
At last count, sepsis was reported to be the leading cause of death in U.S hospital intensive care units {ICU);
accounting for -1 in 5 deaths world-wide; its incidence is anticipated to rise as the populations in developed
countries age; and it was the consensus cause of death assigned to those dying from COVID-19 infection.…
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