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Mechanism of Colonization Resistance

Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 20 Aug 2014Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20252-Hydroxybenzoic AcidAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsBacteriaBiologyButyratesCO2Carbon DioxideCarbonic AnhydrideCell BodyCellsCellular Immune FunctionColiform BacilliDataDevelopmentDrug TargetingEngraftmentEnteric BacteriaEnterobacteriaEnterobacteriaceaeEpitheliumEquilibriumFiberFundingGI microbiotaGastrointestinal microbiotaGeneralized GrowthGoalsGrowthHabitatsHuman FigureHuman bodyHypoxiaHypoxicImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostImpairmentIntermediary MetabolismIntestinalIntestinesInvestigatorsLarge IntestineMediatingMetabolic ProcessesMetabolismMicrobeMiscellaneous AntibioticModelingModificationOutcomeOxygen DeficiencyPathogenesisPathogenicityPredispositionProductionPropertyResearchResearch PersonnelResearch ResourcesResearchersResistanceResourcesSalicylic AcidsScienceShapesShort-Chain Fatty AcidsSignal PathwaySourceSurfaceSusceptibilityTestingTherapeutic InterventionTimeTissue GrowthVolatile Fatty AcidsWorkantibiotic resistant infectionsbacterial disease treatmentbacterial infectious disease treatmentbalancebalance functionblood infectionbloodstream infectionbowelcarbapenem resistance in Enterobacteriaceaecarbapenem-resistant Enterobacteriaceaecolonization resistancecommunity microbesdevelopmentaldrug developmentdysbacteriosisdysbiosisdysbioticenteric microbial communityenteric microbiotaexpectationexperimentexperimental researchexperimental studyexperimentsgastrointestinal microbial floragut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahost microbiotahost microfloraimmune functionimmunosuppressed patientinfection in the bloodinfection of the bloodinfection riskinnovateinnovationinnovativeinsightinterestintervention therapyintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloralarge bowelmembermicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiotamicrobiota derived metabolitesmicrobiota metabolitesmicrofloramicroorganismmicroorganism communitymultispecies consortianew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-typhoid Salmonellanon-typhoidal Salmonellanovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targeto-Hydroxybenzoic Acidontogenyortho-Hydroxybenzoic Acidpathogenpolymicrobial communitypreservationpreventpreventingpublic health relevanceresident microbesresident microfloraresistantsalicylatetrait

Applications closed.

Description preview

PROJECT SUMMARY
Antibiotic treatment impairs colonization resistance, thereby increasing the risk of infection with
Enterobacteriaceae that are frank (e.g. non-typhoidal Salmonella serovars) or opportunistic (e.g.
carbapenem-resistant Enterobacteriaceae) pathogens. However, how the host contributes to
colonization resistance against pathogenic…

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