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Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation

Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 Jan 2021Deadline 14 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technology3DAddressAllelesAllelomorphsAssayBindingBinding SitesBioassayBiological AssayCancersCell BodyCellsChromatinChromatin StructureChromosomal OrganizationChromosomal StructureChromosome OrganizationChromosome StructuresChromosomesCombining SiteDiseaseDisorderDrosophilaDrosophila genusEventFoundationsGene Action RegulationGene ClusterGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenesGeneticGenetic ScreeningGenomeGoalsGrantHealthHuman Cell LineImageInvadedKineticsLinkLiquid substanceMalignant NeoplasmsMalignant TumorMediatingMethodsMolecular InteractionNIGMSNational Institute of General Medical SciencesNucleosomesOligoOligonucleotidesPhasePlayPluripotent Stem CellsReactive SiteResearchRoleSystemTestingYeastschromatin conformation capturechromosome capturechromosome conformation capturecofactordevelopmental diseasedevelopmental disorderfluidfruit flyhuman diseaseimaginginnovateinnovationinnovativeinsightliquidmalignancyneoplasm/cancernoveloligospluripotent progenitorprogramssocial rolethree dimensional

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Description preview

Project Abstract
The overall theme of my research program is to understand the formation mechanism of chromatin structure and
its role in gene regulation. We plan to address this problem at two different levels: 1) at the chromatin /
nucleosome level, we will identify pioneer factors (PFs) and investigate the mechanism underlying nucleosome…

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