grant
Mechanism and therapeutic implication of RNA-modification-mediated codon-biased translation in acute myeloid leukemia
Organization BECKMAN RESEARCH INSTITUTE/CITY OF HOPELocation DUARTE, UNITED STATESPosted 6 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20252-ketoglutarate2-oxoglutarateAML - Acute Myeloid LeukemiaAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAddressAmino AcidsAutomobile DrivingB cell lymphoma 2B-Cell CLL/Lymphoma 2 GeneB-cell lymphoma/leukemia-2B23BCL2BCL2 geneBcl-2Binding SitesBiologyCancersCell BodyCell Communication and SignalingCell SignalingCell SurvivalCell ViabilityCellsChemicalsClinicalCodonCodon NucleotidesCombining SiteDNA ModificationDNA Modification ProcessDNMT3aDataDevelopmentDioxygenasesDrug resistanceDrugsFLK2FLT3FLT3 geneFMS-like tyrosine kinase 3FamilyFms-Related Tyrosine Kinase 3GEM modelGEMM modelGeneralized GrowthGenesGenetic CodeGenetically Engineered MouseGenomic DNAGrowthHematopoiesisHematopoietic Cell TumorHematopoietic Cellular Control MechanismsHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsImmune mediated therapyImmunologically Directed TherapyImmunotherapyIntracellular Communication and SignalingLeukemic progenitor and stem cellMLL rearrangedMLL rearrangementMLL-AF9MLL-rearranged leukemiaMLL/AF9 AMLMalignant CellMalignant Hematopoietic NeoplasmMalignant NeoplasmsMalignant TumorMammaliaMammalsMapsMediatingMedicalMedicationMessenger RNAMitochondriaModelingModificationMolecularMultiomic DataNPMNPM1NPM1 geneNon-Polyadenylated RNANormal CellNuclearOncogenicOrganismPathogenesisPathologicPatientsPharmaceutical PreparationsPlayProcessProductionProliferatingProtein BiosynthesisProteinsRNARNA Gene ProductsReactive SiteRefractoryRelapseReportingResistanceRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRiskRoleSTK-1 kinaseSTK1SamplingSignal TransductionSignal Transduction SystemsSignalingSiteStem Cell Tyrosine Kinase 1StressSurvival RateSystemTestingTherapeuticTissue GrowthTransfer RNATranslatingTranslationsTreatment EfficacyTriplet Codon-Amino Acid AdaptorTumor PromotionValidationXenograft Modelacute granulocytic leukemiaacute granulocytic leukemia cellacute myeloblastic leukemia cellacute myelocytic leukemia cellacute myelogenous leukemia cellacute myeloid leukemiaacute myeloid leukemia cellacute nonlymphocytic leukemia cellalpha ketoglutarateaminoacidbcl-2 Genesbiological adaptation to stressbiological signal transductionblood cancerblood cell formationcancer cellcancer of bloodcancer of the bloodced9 homologdevelopmentaldrivingdrug relapsedrug resistantdrug/agentepitranscriptomicsexperiencefetal liver kinase-2fetal liver kinase-3fitnessgDNAgenetically engineered mouse modelgenetically engineered murine modelglobal gene expressionglobal transcription profilehDNA methyltransferase 3aimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedinhibitorintervention efficacyleukemia stem/initiating cellsleukemia treatmentleukemic progenitorleukemic stem cellleukemic therapyleukemogenesisliving systemmRNAmalignancymembermitochondrialmultiple omic datamutantneoplasm/cancernew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetontogenypharmacologicprotein synthesisrapid growthreaction; crisisresistance to Drugresistance to therapyresistantresistant to Drugresistant to therapyresponseself-renewself-renewalsocial rolestress responsestress; reactiontRNAtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic efficacytherapeutic resistancetherapeutically effectivetherapy efficacytherapy resistanttranscriptometransfer Ribonucleic acidstranslationtransplant modeltreatment resistancevalidationsxenograft transplant modelxenotransplant modelα-ketoglutarateα-oxoglutarateαKG
Description preview
PROJECT SUMMARY:
Among the 20 standard amino acids encoded by 61 codons, 18 are encoded by multiple synonymous codons.
However, the synonymous codon usage is not random, as different organisms or different genes in an organism
prefer using different synonymous codons; such a phenomenon is called codon bias. A mechanism, termed
codon-biased…
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