grant
Measuring stress and epigenetic aging among Black older adults in longitudinal studies of aging
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAD related dementiaADRDAdultAdult HumanAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican ancestryAfrican descentAfro AmericanAfroamericanAgeAgingAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmericanBioethicsBioinformaticsBiologicalBiological FunctionBiological ProcessBiomedical EthicsBiosocialBirthBlackBlack raceCaliforniaCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesChronic stressComplexDNA MethylationDNA Molecular BiologyDataData SetDevelopmentDisadvantagedDiseaseDisorderDisparitiesDisparityEnsureEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpigenetic ageEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationEventFamilyFundingGeneticGenetic DiversityGenetic VariationGerontologyHealthHealth and Retirement StudyHeterogeneityIndividualInvestigatorsInvestmentsK-AwardsK-Series Research Career ProgramsLength of LifeLifeLife CycleLife Cycle StagesLife ExpectancyLinkLiteratureLocationLong-term cohort studyLongevityLongitudinal StudiesLongitudinal cohort studyMeasuresMedicalMentorshipMolecularMolecular BiologyMorbidityMorbidity - disease rateNatureOutcomeParturitionPathway interactionsPatternPhasePhenotypePhysical FunctionPopulationProcessPublicationsResearchResearch Career ProgramResearch DesignResearch MethodologyResearch MethodsResearch PersonnelResearch ResourcesResearchersResourcesSamplingSampling StudiesSchoolsScientific PublicationStressStudy TypeTimeTrainingUniversitiesVariantVariationWorkaccelerated agingaccelerated biological ageaccelerated biological agingaccelerated epigenetic ageaccelerated epigenetic agingaccelerated pace of epigenetic agingacceleration in epigenetic ageadulthoodage accelerationage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging delayaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging induced epigenetic changeaging processaging related alterationsaging related changesaging specific alterationsaging specific changesaging-associated epigenetic changeaging-related epigenetic changealterations with ageattenuate agingbiodemographybiologicbiological agechanges with agecognitive functioncohortdata reductiondecelerate agingdelay age relateddevelopmentaldifferences in healthdisparity in healthearly onsetenvironmental stressesenvironmental stressorepidemiologicepidemiologicalepigenetic agingepigenetic mechanisms in agingepigenetic modifications in agingepigenetic regulation of agingepigeneticallyethnic subgroupethnicity groupexperiencefaster epigenetic agingfaster rates of epigenetic aginggenomic datagenomic datasetgerontologichallmarks of aginghealth differencehealth disparityimprovedincreased epigenetic ageincreased epigenetic agingincreased rates of epigenetic aginginsightlife courselong-term studylongitudinal data setlongitudinal datasetlongitudinal outcome studiesmortalitymulti-ethnicmultidisciplinarymultiethnicnext generationold ageolder adultolder adulthoodpathwaypause agingpillars of agingpopulation healthpostpone age relatedrapid epigenetic agingresearch and methodsresponseretards agingskillsslow agingslow down agingslow the rate of agingsocial disadvantagesocial disparitiessocial inequalitysocial stresssocially stressedstressorstudy designyounger age
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Stress is a fundamental pathway to variation in health and aging. African American older adults experience more stressors over their life course and age faster than other groups as evidenced by earlier onset of most diseases and declines in biological, physical and cognitive functioning. One of the underlying mechanisms connecting stress to…
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