grant
Measuring and Programming Piconewton Receptor Forces for Synthetic Mechanobiology
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2026AddressAppleBindingBiocompatible MaterialsBiologicalBiological FunctionBiological ProcessBiologyBiomaterialsBody TissuesCancersCell BodyCell TherapyCell-Extracellular MatrixCell-Mediated CytolysisCell-Mediated LympholysisCellsCellular CytotoxicityCellular Immune FunctionClottingCoagulationCoagulation ProcessCommunitiesDefectDiseaseDisorderECMEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEngineeringExhibitsExtracellular MatrixFibroblastsFluorescenceImmunologyIn VitroIndividualInvadedKnowledgeLearningLiftingLymphocyte CytotoxicityLymphocytotoxicityMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant CellMalignant NeoplasmsMalignant TumorMalus domesticaMeasuresMechanoreceptorsMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMolecular InteractionNeoplasm MetastasisReceptor ProteinSecondary NeoplasmSecondary TumorT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteTechnologyTestingTimeTissuesTransmissionVisible LightVisible Light RadiationVisible RadiationWorkactivate T cellsanti-cancer immunotherapyanticancer immunotherapybiologicbiological materialcancer cellcancer immunotherapycancer metastasiscell based interventioncell mediated cytotoxicitycell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapyexperimentexperimental researchexperimental studyexperimentsimmune functionimmune-based cancer therapiesimmunotherapy for cancerimmunotherapy of cancermalignancymechanical forcemechanical propertiesmigrationneoplasm/cancernovelreceptorthymus derived lymphocytetransmission processtumor cell metastasisviscoelasticity
Description preview
Project Summary:
Mechanical forces are critical in diverse biological processes, including coagulation, cancer metastasis,
embryonic development, and immune function. Individual receptors exert forces at the piconewton scale, one
trillionth the force required to lift an apple. Our lab seeks to develop novel “mechanoimaging” technologies that…
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