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Measuring and Modeling the Effects of Reticular Lamina Flexibility on Outer Hair Cell Bundle Phase and Cochlear Amplification

Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Mar 2023Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modelingAffectAirAnatomic SitesAnatomic structuresAnatomyAnimalsApicalAuditory systemAutopsyBasilar MembraneBindingBiologicalBody TissuesCapsulesCell BodyCell LocomotionCell MigrationCell MovementCellsCellular MigrationCellular MotilityCharacteristicsCochleaCochlear OrganComputer ModelsComputerized ModelsCortis OrganDataDiagnosisDiameterDoppler OCTEar CanalElementsEpitheliumExternal Acoustic MeatusExternal auditory canalFrequenciesFutureGerbilsH elementHearingHearing LossHumanHydrogenHypoacusesHypoacusisImageImaging technologyInternal EarKnowledgeLabyrinthLengthLocationMeasurementMeasuresMechanicsMembraneMethodsMiceMice MammalsModelingModern ManModernizationMolecular InteractionMotilityMotionMurineMusNatureOCT TomographyOptical Coherence TomographyOrgan of CortiOuter Hair CellsOutputPathologyPersonsPhalanxPhasePhysicsPillar CellProcessRadialRadiusResearchResolutionRestSensoryShapesSourceSpiral OrganSpiral Organ of CortiStapesStructureStructure-Activity RelationshipSystemTechnologyTestingTissuesWild Type MouseX-ray microtomographyXray microtomographybasebasesbiologicbonecapsulecell motilitychemical structure functioncochlear windowcomputational modelingcomputational modelscomputer based modelscomputerized modelingdysfunctional hearingfenestra cochleaeflexibilityflexiblegood hearinghealthy hearinghearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmentimagingimprovedin vivoinner earinsightmechanicmechanicalmembrane structuremetermicro CTmicro computed tomographymicroCTmicrotomographymosaicnano meter scalenano meter sizednanometernanometer scalenanometer sizednanoscalenecropsynormal hearingnovel imaging technologyoptical Doppler tomographyoptical coherence Doppler tomographyparticlepostmortempressureresolutionsresponseround windowsoundstructure function relationshiptectorial membranethree dimensionalthree-dimensional modelingvibrationwildtype mouse

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Description preview

ABSTRACT
The mammalian auditory system has evolved into a biological marvel with high sensitivity that can largely be
traced to nonlinear amplification by the organ of Corti (OoC)—the sensory epithelium within the cochlea of the
inner ear. Despite decades of research, the inaccessibility of the inner ear’s bony capsule and the technological…

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