grant
Measuring and Mapping Functional Properties of Extracellular Matrix (ECM)
Organization EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AddressAgeAgingAgreementArchitectureAtomic Force MicroscopesBehaviorBindingBiochemicalBiologic ModelsBiologicalBiological FunctionBiological MimeticsBiological ModelsBiological ProcessBiomechanicsBiomimeticsBody TissuesBrainBrain Nervous SystemCarbomer-940CartilageCartilaginous TissueCell BodyCell DifferentiationCell Differentiation processCell Growth in NumberCell MultiplicationCell ProliferationCell-Extracellular MatrixCellsCellular ProliferationCharacteristicsChargeChemicalsChondroitin SulfatesCollagenComplexDataDegenerative ArthritisDegenerative polyarthritisDevelopmentDiseaseDisorderECMEarly DiagnosisElasticityElectric Field MicroscopesElementsEncephalonEngineering / ArchitectureEnsureEnvironmentEquilibriumExhibitsExtracellular MatrixFillerGelGlycansGrowth AgentsGrowth FactorGrowth SubstancesH+ elementHumanHyaluronic AcidHydrationHydration statusHydrogelsHydrogen IonsHydrogen OxideImmobilizationIn VitroIonsJointsKnowledgeKnowledge acquisitionLateral Force MicroscopesLatex RubberLawsLengthLiquid substanceLoad BearingMR ImagingMR TomographyMRIMRIsMagnetic Force MicroscopesMagnetic Resonance ImagingMapsMeasurementMeasuresMechanicsMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModel SystemModelingModern ManModulusMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMolecular TransportMotionNMR ImagingNMR TomographyNatureNuclear Magnetic Resonance ImagingOsmosisOsmotic PressureOsteoarthritisOsteoarthrosisPathologicPhysiologicPhysiologicalPilot ProjectsPolymersPolysaccharidesPolyvinyl AlcoholProcessPropertyProteinsProteins Growth FactorsProteoglycanProtonsRelaxationResearch DesignResearch SpecimenResistanceResolutionRoleRubberSamplingScanningScanning Probe MicroscopesScanning Thermal MicroscopesScanning Tunneling MicroscopesSpecimenSpinal ColumnSpineStressStructureStudy TypeSupporting CellSwellingSystemTechniquesTimeTissue SampleTissuesTransport ProcessTraumaVariantVariationVertebral columnVisualizationWaterWeight BearingWeight-Bearing stateZeugmatographyabsorptionagesaggrecanbackbonebalancebalance functionbiologicbiomechanicalbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbrain tissuecarbopol 940cartilage degenerationcartilage degradationcellular differentiationchemical propertyconformationconformationalconformational stateconformationallyconformationscrosslinkdegenerative joint diseasedensitydevelopmentalearly detectionexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblefluidhomopolymer Ethenolhydrogen sulfate Chondroitinhypertrophic arthritisimage-based methodimaging methodimaging modalityimaging spectroscopyin vivoinstrumentjoint mobilityjoint mobilizationjoint movementliquidmacromoleculemechanicmechanicalmechanical behaviormechanical propertiesmolecular dynamicsnanometernatural Rubbernew approachesnovelnovel approachesnovel strategiesnovel strategyorthopedic freezingparticlepilot studypolyacrylic acidpolymerpolymericpressureresistantresolutionsresponsescaffoldscaffoldingself assemblysocial rolespectroscopic imagingstudy designtheoriestissue maptissue mappingvaporvirtualviscoelasticity
Description preview
The extracellular matrix (ECM) has multiple functions in tissues: it provides structural support for cells, determines tissue rigidity and elasticity, acts as a reservoir of growth factors, and provides an environment for remodeling in response to developmental, physiological and pathological challenges. The multiple functions and complex…
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