grant
MD Anderson Cancer Center EDRN- Clinical Validation Center for Early Detection of Ovarian Cancer with a multiple marker algorithm
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 5 May 2016Deadline 31 May 2028
NIHUS FederalResearch GrantFY20252aR phosphoprotein I2ar peptide3-10CAMCF-IAdult Folate Receptor 1Adult Folate-Binding ProteinAlgorithmsAntigensAntioncogene Protein p53ArizonaAssayAutoantibodiesBenignBioassayBiological AssayBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood SerumBlood TestsBody TissuesCA-125CA-125 AntigenCA125CTAGCTAG1CTAG1 geneCTAG1BCTAG1B GeneCXCL8Cancer Antigen 125Cancer CenterCancer DetectionCarbohydrate Antigen 125Cellular Tumor Antigen P53CollaborationsCombination Drug TherapyCommentCommentaryComplementComplement ProteinsComplexComputer ModelsComputerized ModelsDebulkingDiagnosisDiseaseDisorderEDRNEP4ESO1Early Detection Research NetworkEarly DiagnosisEchographyEchotomographyEditorial CommentEndometrial CancerEndometrial CarcinomaEndometrium CancerEndometrium CarcinomaEpididymal Secretory Protein E4Epithelial ovarian cancerEta-1 proteinEta-1-Op proteinEvaluationFOLRFOLR1FOLR1 geneFolate Receptor AlphaGCP1General HospitalsGoalsGrantHE4Hematologic TestsHematological TestsHematology TestingIL-8IL8IL8 geneImageIndividualInvestigatorsK60LAGE2BLeadLesionLinkMOv18Major Epididymis-Specific Protein E4Malignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMassachusettsMeasurementMeasuresMedical UltrasoundNY-ESO-1National Detection Research NetworkOncoprotein p53Operative ProceduresOperative Surgical ProceduresOvarianOvarian Cancer-Associated AntigenOvaryOvary CancerP53PatientsPb elementPeer ReviewPelvicPelvic RegionPelvisPhosphoprotein P53Phosphoprotein pp53PlasmaPlasma SerumPolychemotherapyPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePredictive ValueProtein TP53Published CommentPublishingPutative Protease Inhibitor WAP5RecurrenceRecurrentRecurrent Malignant NeoplasmRecurrent Malignant TumorRecurrent diseaseRelapsed DiseaseReportingResearch PersonnelResearch SpecimenResearchersReticuloendothelial System, Serum, PlasmaRiskSCYB8SamplingScreening for Ovarian CancerSecond LookSecond Look SurgerySerumSiteSpecificitySpecimenSurgicalSurgical InterventionsSurgical ProcedureSurgical RevisionTP53TP53 geneTRP53TSG-1TechnologyTestingTimeTissue SampleTissuesTumor DebulkingTumor Protein p53Tumor Protein p53 GeneUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUnited KingdomUnited StatesUniversitiesVaginaViewpointWAP Four-Disulfide Core Domain Protein 2WAP5WFDC2WFDC2 geneWomanadvanced diseaseadvanced illnessafter menopauseannual screeningautoimmune antibodyautoreactive antibodyb-ENAPbio-markersbiologic markerbiomarkerbiomarker identificationbone sialoprotein 1bone sialoprotein Icancer recurrencechemotherapyclinical validationcollaborative trialcombination chemotherapycombination pharmacotherapycomplementationcomputational modelingcomputational modelscomputer based modelscomputerized modelingcytoreductive surgerydJ461P17.6diagnostic ultrasounddisease heterogeneityearly T-lympocyte activation-1 proteinearly biomarkersearly detectionearly detection biomarkersearly detection markersfollowing menopauseheavy metal Pbheavy metal leadidentification of biomarkersidentification of new biomarkersimagingimmunogenimprovedmarker identificationmortalitynew markernovel biomarkernovel markeroperationoperationsosteopontinovarian cancerovarian cancer detectionovarian cancer early detectionovarian cancer early screeningp53 Antigenp53 Genesp53 Tumor Suppressorpast menopausepost-menopausalpostmenopausalpostmenopausal statuspreservationprotein p53rapid assayrapid testrapid testsroutine screeningscreeningscreeningssecreted phosphoprotein 1self reactive antibodysialoprotein 1sonogramsonographysound measurementsurgerysurgical cytoreductiontumor cytoreductionultrasoundultrasound imagingultrasound scanning
Description preview
ABSTRACT: Advances in cytoreductive surgery and combination chemotherapy have improved 5-year survival
in patients with epithelial ovarian cancer, but the rate of cure remains essentially unchanged over the last two
decades. Computer models suggest that detection of ovarian cancer in early stage (I-II) could improve rates of
cure by 10-30%. In two…
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