grant
Maternal obesogenic diet-induced changes in embryo and fetal DNA methylation programming
Organization OREGON HEALTH & SCIENCE UNIVERSITYLocation PORTLAND, UNITED STATESPosted 13 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AccelerationAdverse effectsAffectBMIBMI percentileBMI z-scoreBS-seqBackBirthBisulfite-based sequencingBlastosphereBody TissuesBody Weight decreasedBody mass indexCannot achieve a pregnancyCarbohydratesCell BodyCell Communication and SignalingCell SignalingCellsCells Placenta-TissueCenter for Translational Science ActivitiesChromosomesConceptionsConsumptionControl GroupsCopy Number PolymorphismCord BloodDNADNA MaintenanceDNA MethylationDNA StabilityDNA seqDNA sequencingDNAseqDataDefectDeoxyribonucleic AcidDeveloping fetusDevelopmentDevelopmental DelayDevelopmental Delay DisordersDietDietary InterventionDifficulty conceivingDisproportionate number of menDisproportionately impacts malesDisproportionately in menDorsumEPH GestosisEmbryoEmbryo DevelopmentEmbryo and Fetal DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEmbryonic TissueEmbryonic and Fetal DevelopmentEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthicsEventExhibitsExposure toExpression SignatureFat-Restricted DietFatsFatty acid glycerol estersFecundabilityFecundityFemaleFertilityFertilizationFertilization failureFertilization in VitroFetal DevelopmentFetal TissuesFetusFrequenciesFutureGene ExpressionGene Expression ProfileGenesGenetic ImprintingGenomic ImprintingGenomic SegmentGestationGlucose Binding ProteinGlucose Transport ProteinGlucose TransporterGrantGrowth AgentsGrowth FactorGrowth SubstancesHealthHumanImpairmentIncidenceIndividualInfertilityInsulin ResistanceIntermediary MetabolismIntracellular Communication and SignalingKidneyKidney Urinary SystemLinkLiverLow-Fat DietM mulattaM. mulattaMacacaMacaca mulattaMacaca rhesusMacaqueMammaliaMammalsMaternal MortalityMaternal NutritionMaternal dietMediatingMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismMethylationModelingModern ManModificationMolecularMothersNon-Polyadenylated RNANormal PlacentomaNutrition InterventionsNutritional InterventionsObesityOocytesOutcomeOvarian StimulationsOver weightOverweightOvocytesParental ImprintingParturitionPhenotypePlacentaPlacenta Embryonic TissuePlacental DevelopmentPlacental InfarctionPlacentationPlacentomePre-EclampsiaPre-implantation Embryo DevelopmentPre-implantation developmentPredispositionPreeclampsiaPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy ToxemiasPregnant WomenPreimplantation EmbryoPreimplantation Embryo DevelopmentPreimplantation developmentPremature BirthPrematurely deliveringPreterm BirthPrimatesPrimates MammalsProcessProteins Growth FactorsProteinuria-Edema-Hypertension GestosisQuetelet indexRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqRecommendationReportingReproductionReproductive ProcessRhesusRhesus MacaqueRhesus MonkeyRibonucleic AcidRisk FactorsRoleSamplingSignal TransductionSignal Transduction SystemsSignalingSpecific Child Development DisordersSpermSpermatozoaSpleenSpleen Reticuloendothelial SystemSusceptibilityTest-Tube FertilizationThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTissuesUmbilical Cord BloodVillousWeight GainWeight IncreaseWeight LossWeight ReductionWomanWomen's cohortWorkadiposityadverse pregnancy outcomebefore conceptionbiological signal transductionbisulfite sequencingbisulfite-seqblastocystblastulabody weight gainbody weight increasebody weight losschildbearing agecohortcohort in womencohort on womencompare to controlcomparison controlcomplications during pregnancycopy number variantcopy number variationcorpulencedevelopmentaldiet controldiet interventiondietarydietary controldietsdisproportionately affects malesdisproportionately affects mendisproportionately concentrated among mendisproportionately distributed among mendisproportionately higher among mendisproportionately impacts mendisproportionately occurs in menembryo qualityembryo tissueembryo/fetusentire genomeenvironmental riskepigeneticallyethicalexpectant motherexpectant womenexpecting motherexpecting womenexperiencefemale cohortfertile agefertility assistancefertility cessationfertility interventionsfertility lossfertility treatmentfertilizationsfetalfetal cord bloodfetal programmingfetus tissuefull genomegene expression patterngene expression signaturegenome segmentgenomic regionhepatic body systemhepatic organ systemimplantationimprovedin uteroindividuals who are pregnantinfertileinfertility treatmentinsightinsulin resistantinsulin tolerancelater in lifelater lifelife style interventionlifestyle interventionlongitudinal designlongitudinal experimental designlongitudinal research designlongitudinal study designmalemale biasmale predominancematernal adipositymaternal deathmaternal nutrition during pregnancymaternal obesitymen disproportionately diagnosedmen disproportionately experiencemen experience disproportionate ratesmethylation patternmother nutritionnon-human primatenonhuman primateobese patientsobesity-promoting dietobesogenic Western-style dietobesogenic dietobesogenic high fat dietobesogenic western dietoffspringoocyte maturationpatients with obesitypeople who are pregnantpre-eclampticpre-implantation embryopreconceptionpredominantly affecting menpregnancy toxemia/hypertensionpregnancy-related complicationspregnantpregnant femalespregnant motherspregnant peoplepregnant populationspreimplantationpremature childbirthpremature deliverypreterm deliveryprior to conceptionpro-obesity dietrenalreproductivereproductive agereproductive functionreproductive yearsresponsesexsocial rolesperm cellthose who are pregnanttime-to-pregnancytranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranslational research centertranslational sciences centerwestern dietwestern-style dietwestern-type dietwhole genomewomen who are pregnantwt gainwt-losszoosperm♀♂
Description preview
PROJECT SUMMARY
Obesity in reproductive-age women has sharply increased over the past few decades and is expected to continue
to rise for the foreseeable future. Besides a greater likelihood of pregnancy complications, such as preeclampsia
and preterm birth, obese women are also more likely to experience severe pregnancy outcomes, including…
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